Weight Management Library
Medically reviewed explanations of the terms, treatments and concepts that come up in weight management — written for patients.
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Screening
24-Hour Dietary Recall
A 24-hour dietary recall is a structured interview in which a person describes everything eaten and drunk in the previous day, with portions and preparation, to reveal patterns that a quick history misses.
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Body Composition
3D Body Scanning
A 3D body scan uses cameras or depth sensors to build a full digital model of your body, giving accurate circumferences and shape changes without radiation.
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Body Composition
A Body Shape Index (ABSI)
A Body Shape Index (ABSI) is a formula that measures how wide your waist is for your height and weight; a higher score points to a more central shape and a higher health risk than BMI alone suggests.
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Procedures
Abdominoplasty (Tummy Tuck)
An abdominoplasty, or tummy tuck, is surgery that removes loose skin and fat from the lower belly and tightens the abdominal muscles.
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Conditions
Acanthosis Nigricans
Acanthosis nigricans is a skin condition causing dark, velvety patches — a visible sign of insulin resistance linked to excess weight.
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Psychological
Acceptance and Commitment Therapy (ACT)
Acceptance and Commitment Therapy (ACT) is a form of counselling that helps people respond skilfully to cravings and difficult emotions instead of fighting or being ruled by them.
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Lifestyle
Active Commuting and Weight
Using walking, cycling, or public transport for daily travel to naturally build physical activity into routines and support healthy weight management.
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Foundations
Adaptive Thermogenesis
The body's metabolic defence mechanism that disproportionately slows energy expenditure during and after weight loss.
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Nutrition
Added Sugars
Added sugars are sugars and syrups added to foods during processing, which contribute empty calories and are linked to obesity, diabetes, and fatty liver disease.
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Psychological
ADHD and Obesity
Attention deficit hyperactivity disorder and obesity occur together far more often than chance would predict, partly because impulsivity and altered reward processing make eating cues harder to resist.
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Body Composition
Adipocyte Hyperplasia
Adipocyte hyperplasia means the body builds more fat cells rather than only enlarging existing ones, and it shapes how severe obesity becomes and how it behaves after weight loss.
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Body Composition
Adipocyte Hypertrophy
Adipocyte hypertrophy is the enlargement of existing fat cells to store more fat; stretched, oversized fat cells leak fatty acids, attract inflammation and are closely linked to insulin resistance.
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Foundations
Adipogenesis
The biological process by which the body creates new fat cells from precursor cells, influencing energy storage and metabolism.
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Foundations
Adipokines
Bioactive signalling proteins secreted by fat cells that regulate metabolism, inflammation, and appetite throughout the body.
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Hormones
Adiponectin
Adiponectin is a hormone produced by your fat tissue that helps your body use insulin properly and protects against inflammation.
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Foundations
Adipose Tissue
Adipose tissue is the body's specialised fat storage tissue that plays a critical role in energy balance, hormone production, and metabolic health.
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Foundations
Adipose Tissue Dysfunction
Adipose tissue dysfunction — 'sick fat' — means fat cells are no longer storing energy safely, leaking fat into the blood and driving insulin resistance and inflammation.
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Foundations
Adipose Tissue Expandability Hypothesis
The adipose tissue expandability hypothesis explains that metabolic harm comes from fat overflowing into organs once the safe storage capacity of subcutaneous fat is full.
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Foundations
Adipose Tissue Fibrosis
When fat tissue grows faster than its blood supply, chronic obesity drives collagen deposition and scarring inside it, which stiffens the tissue, limits further storage and promotes insulin resistance.
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Foundations
Adiposity Rebound
Adiposity rebound is the natural rise in body fat that happens in early childhood after a low point around age 5–6; when it occurs earlier than usual, it can signal a higher risk of obesity later in life.
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Hormones
Adipsin (Complement Factor D)
Adipsin, also called complement factor D, is a protein made largely by fat cells that drives part of the immune complement system and generates signals promoting fat storage; its levels change in obesity and diabetes.
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Procedures
Adjustable Gastric Band
A reversible bariatric procedure using an adjustable silicone band around the stomach to restrict food intake.
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Procedures
Adolescent Bariatric Surgery
Adolescent bariatric surgery is weight-loss surgery performed in teenagers with severe obesity who have not responded to intensive lifestyle and medical treatment.
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Hormones
Adropin
Adropin is a hormone made mainly by the liver and brain that helps the body burn fat and use glucose efficiently - levels are usually lower in obesity and insulin resistance.
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Psychological
Adverse Childhood Experiences (ACEs) and Obesity
Adverse childhood experiences - abuse, neglect and household adversity before the age of 18 - are linked in a dose-dependent way to a higher risk of adult obesity, largely through long-term stress, sleep and appetite pathways.
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Hormones
Agouti-Related Peptide (AgRP)
AgRP is one of the brain's two main hunger signals - a neuropeptide that turns appetite on when energy stores fall and switches off after you eat.
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Body Composition
Air Displacement Plethysmography (Bod Pod)
The Bod Pod is an egg-shaped machine that measures your body fat percentage while you sit quietly inside it for a few minutes.
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Lifestyle
Alcohol and Weight Management
Alcohol adds calories, lowers restraint and stalls fat burning, so cutting back supports weight loss.
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Hormones
Aldosterone and Obesity
Aldosterone is the hormone that makes the kidneys retain sodium and water; excess weight raises aldosterone activity, contributing to high blood pressure and salt and fluid retention.
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Psychological
All-or-Nothing Thinking
All-or-nothing thinking is a pattern of viewing eating and weight loss in extremes — perfect or failed — which makes small setbacks derail progress.
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Screening
ALT (Alanine Aminotransferase)
ALT is a liver enzyme measured in a standard blood test, and a mildly raised level is the most common first signal that fat is accumulating in the liver - which is why it is checked during weight management.
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Screening
Ambulatory Blood Pressure Monitoring (ABPM)
Ambulatory blood pressure monitoring records blood pressure automatically over 24 hours, including during sleep, giving a far more reliable picture than a single clinic reading.
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Hormones
Amylin
Amylin is a hormone released with insulin after meals that slows stomach emptying and signals fullness, helping to regulate appetite and blood sugar.
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Complications
Anaesthesia and Obesity
Obesity makes general anaesthesia more demanding - a higher-risk airway, faster oxygen desaturation and a greater chance of breathing problems after surgery.
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Body Composition
Android and Gynoid Fat Distribution
Android (apple-shaped) and gynoid (pear-shaped) fat distribution describe where the body stores fat — and the location matters more than the total amount for metabolic health.
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Screening
Ankle-Brachial Index
The ankle-brachial index compares the blood pressure at your ankle with your arm to detect narrowed arteries in the legs - a common, silent problem in people with diabetes or excess weight.
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Foundations
Anorexigenic Signals
Anorexigenic signals are the body's natural stop-eating messages — chemical messengers that promote fullness and suppress appetite after eating.
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Body Composition
Anthropometry
Anthropometry is the measurement of body size and proportions - weight, height, waists, skinfolds and limb circumferences - the simple, portable first line of body composition assessment.
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Nutrition
Anti-Inflammatory Diet
A diet rich in fruits, vegetables, and omega-3s that reduces chronic inflammation and supports healthy weight loss.
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Medications
Anti-Obesity Medications (AOMs)
Anti-obesity medications are doctor-prescribed medicines that help with weight loss when diet and exercise alone have not been enough.
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Medications
Antibiotics and Weight Gain
Repeated antibiotic courses, especially in the first two years of life, are associated with a small increase in later body weight through their effect on gut bacteria.
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Medications
Antidepressants and Weight Gain
Antidepressant medicines differ widely in their effect on weight, with some adding several kilograms over months while others are weight-neutral or cause early weight loss.
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Medications
Antihistamines and Weight Gain
Antihistamines that block the H1 receptor - the everyday hay-fever and allergy tablets - have been linked to higher body weight in long-term users.
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Medications
Antipsychotics and Weight Gain
Antipsychotic medicines, especially olanzapine and clozapine, commonly cause substantial weight gain and metabolic changes, so weight and blood tests must be monitored.
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Procedures
Antireflux Surgery After Bariatric Surgery
About half of people with a body mass index over 30 have reflux, so the choice of weight-loss operation and the treatment of reflux have to be planned together.
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Medications
Antiretroviral Therapy and Weight Gain
Modern HIV treatment commonly leads to weight gain, particularly combinations built on integrase inhibitors and tenofovir alafenamide - and the gain can be managed without stopping treatment.
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Psychological
Anxiety and Weight Management
Anxiety and weight management are closely linked — stress and worry can change eating habits, and carrying excess weight can in turn fuel anxiety, creating a cycle that is best broken with professional support.
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Hormones
Apelin
Apelin is a signalling protein released by fat tissue, blood vessel walls and the heart that improves the body response to insulin, helps blood vessels relax and is being studied as a link between obesity and heart and metabolic disease.
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Screening
Apolipoprotein B (ApoB)
Apolipoprotein B (ApoB) is a blood test that counts the particles that carry harmful cholesterol — a more precise heart-risk gauge than LDL cholesterol alone.
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Body Composition
Appendicular Skeletal Muscle Mass Index (ASMI)
The appendicular skeletal muscle mass index divides the muscle in the arms and legs by height squared, giving a single number used to define low muscle mass in sarcopenia - and it can be low in people who are overweight.
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Foundations
Appetite Regulation
The neuroendocrine system of hormones and brain signals that controls hunger and fullness, targeted by modern weight loss medications.
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Screening
Arterial Stiffness
Arterial stiffness measures how rigid the large arteries have become - rising stiffness with obesity signals a higher risk of heart attack, stroke and kidney damage, and it is measured with a simple, painless pulse test.
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Nutrition
Artificial Sweeteners
Artificial sweeteners provide sweetness without calories, and may help reduce sugar intake — but their long-term effects on weight and metabolism are complex.
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Procedures
Aspiration Therapy
A minimally invasive procedure that removes a portion of stomach contents after meals to reduce calorie absorption.
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Hormones
Asprosin
Asprosin is a hormone released by fat tissue during fasting that signals the liver to release glucose and the brain to increase appetite, and its levels are raised in obesity, insulin resistance and type 2 diabetes.
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Conditions
Asthma and Obesity
Obesity increases the risk of developing asthma and makes existing asthma harder to control — and losing weight can meaningfully improve asthma symptoms.
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Complications
Atrial Fibrillation and Obesity
Atrial fibrillation is an irregular and often fast heartbeat that can cause palpitations, breathlessness and a higher risk of stroke.
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Conditions
Bardet-Biedl Syndrome
A rare genetic ciliopathy characterised by severe early-onset obesity caused by impaired hypothalamic appetite regulation, requiring specialised multidisciplinary care.
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Procedures
Bariatric Endoscopy
Bariatric endoscopy uses a thin flexible tube passed through the mouth to perform weight-loss procedures on the stomach without surgery or scars.
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Procedures
Bariatric Prehabilitation
A structured pre-surgery programme of diet, exercise, and lifestyle changes that prepares patients physically and mentally for bariatric procedures.
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Procedures
Bariatric Surgery
Surgical procedures that alter the digestive system to promote weight loss.
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Body Composition
Basal Metabolic Rate
Calories your body burns at complete rest — the foundation of energy expenditure.
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Psychological
Behavioural Economics and Weight Management
Behavioural economics explains why knowing what to eat is not enough: present bias, defaults and portion cues shape eating, and small changes to the food environment shift choices modestly but reliably.
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Lifestyle
Behavioural Therapy for Weight Loss
A psychological approach to weight management that helps change eating habits, identify triggers, and build sustainable healthy behaviours.
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Body Composition
Beige Adipocytes
Beige adipocytes are brown-fat-like cells that appear inside white fat depots in response to cold or adrenergic signalling and burn energy as heat rather than storing it.
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Conditions
Benign Prostatic Hyperplasia and Obesity
Obesity and the metabolic syndrome are associated with a larger prostate and worse urinary symptoms, and losing weight measurably improves both.
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Medications
Beta-Blockers and Weight Gain
Beta-blockers taken for blood pressure or heart rate can add a kilogram or two over the first months, and the effect is largest in people who are already overweight.
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Psychological
Big Five Personality Traits and Weight Management
Of the five broad personality traits, conscientiousness is the one consistently linked to lower body weight and to keeping weight off, while high neuroticism and impulsivity predict weight fluctuation.
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Hormones
Bile Acids and Weight Regulation
Bile acids digest fat, but they also act as hormones through the FXR and TGR5 receptors - and after gastric bypass they rise two to three fold, helping drive the GLP-1 surge that improves blood sugar.
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Procedures
Biliopancreatic Diversion
A major malabsorptive bariatric surgery that reduces nutrient absorption by rerouting the small intestine, producing substantial and sustained weight loss.
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Medications
Bimagrumab
Bimagrumab is an investigational medication that aims to build muscle while reducing body fat — a new approach to weight loss being studied in clinical trials.
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Psychological
Binge Eating Disorder
A serious eating disorder involving recurrent episodes of uncontrolled overeating.
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Procedures
Bioelectrical Impedance Analysis (BIA)
A quick, non-invasive test that uses a small electrical signal to estimate your body fat percentage, muscle mass, and hydration levels.
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Lifestyle
Blue Light and Weight
Evening blue light from screens disrupts sleep hormones and metabolism, contributing to weight gain — reducing exposure supports weight management.
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Body Composition
BMI
Body Mass Index — a screening tool using height and weight to assess weight status.
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Body Composition
Body Adiposity Index (BAI)
The Body Adiposity Index (BAI) is a simple way to estimate how much of your body is made up of fat using only your height and the size of your hips.
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Body Composition
Body Cell Mass
Body cell mass is the oxygen-using, potassium-rich, working part of the body - roughly 40% of weight in a healthy adult - and it is the compartment that shrinks in starvation, illness and ageing.
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Psychological
Body Checking
Body checking is the habit of repeatedly weighing, measuring or inspecting your body, and it can actually increase body dissatisfaction and interfere with weight loss.
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Screening
Body Composition Analysis
Measurement of body fat percentage, muscle mass, and distribution.
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Procedures
Body Contouring
Body contouring is surgery to remove loose, excess skin and reshape remaining tissue after significant weight loss.
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Psychological
Body Dysmorphia
Body dysmorphia is a mental health condition involving obsessive focus on perceived appearance flaws, which can complicate weight-loss efforts.
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Body Composition
Body Fat Percentage
Body fat percentage measures the proportion of body weight from fat, providing a more accurate health picture than BMI alone.
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Psychological
Body Image
Body image is how you see, think and feel about your body — and in weight management it shapes motivation, eating behaviour and emotional wellbeing.
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Body Composition
Body Recomposition
Body recomposition means losing fat while gaining or preserving muscle, so the scale may barely move while your body genuinely improves.
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Foundations
Body Roundness Index (BRI)
A body shape index that uses waist circumference and height to estimate abdominal fat distribution, providing more accurate health risk assessment than BMI alone.
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Body Composition
Body Surface Area (BSA)
Body surface area is an estimate of the total area of the skin, calculated from height and weight, and used mainly to work out drug doses and to scale physiological measurements.
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Body Composition
Bone Health and Obesity
Obesity and weight loss both affect bone strength — extra weight loads the bones, but rapid weight loss can thin them, so bones need protection during any weight loss journey.
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Psychological
Boredom Eating
Boredom eating is eating for stimulation rather than hunger - a learned habit triggered by idle moments, and one of the most fixable patterns in weight management.
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Procedures
Brachioplasty
Brachioplasty is arm-lift surgery that removes excess skin and fat from the upper arm after major weight loss, at the cost of a permanent scar along the inner arm.
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Foundations
Brown Adipose Tissue
Brown adipose tissue is a special type of fat that burns calories to produce heat, playing a unique role in energy expenditure and metabolic health.
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Medications
Bupropion
Bupropion is a medication that affects brain chemicals linked to appetite and cravings, and may support weight loss as part of a comprehensive programme.
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Screening
C-Peptide
C-peptide is a blood marker that shows how much insulin your pancreas is actually producing — it helps doctors pinpoint the true cause of high blood sugar.
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Lifestyle
Caffeine and Weight Management
A mild stimulant that briefly boosts metabolism and curbs appetite but has limited effect on long-term weight loss.
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Medications
Cagrilintide
A long-acting amylin analogue given as a weekly injection to enhance feelings of fullness and reduce food intake.
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Body Composition
Calf Circumference
Calf circumference is a tape measurement around the widest part of the lower leg - a quick, validated way to estimate muscle mass, and a key check that weight is coming off as fat rather than as muscle.
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Nutrition
Caloric Deficit
Consuming fewer calories than your body burns, the foundation of weight loss.
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Lifestyle
Calorie Tracking
Calorie tracking means recording what you eat and drink to see your actual energy intake.
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Complications
Cancer and Obesity
Carrying excess body fat has been linked to a higher risk of developing at least 13 different types of cancer, including breast, bowel and womb cancers.
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Nutrition
Capsaicin and Weight Management
The active compound in chilli peppers that may boost calorie burning and reduce appetite as a natural adjunct to weight management.
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Foundations
Carbohydrate-Insulin Model of Obesity
The carbohydrate-insulin model says that refined carbohydrates drive insulin release, which stores fat and leaves the body under-fuelled, causing hunger and weight gain.
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Screening
Cardiopulmonary Exercise Testing (CPET)
Cardiopulmonary exercise testing measures breathing, oxygen use and heart rhythm while a patient pedals or walks against rising resistance, giving an objective picture of fitness and surgical risk.
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Complications
Cardiovascular Disease
Heart and blood vessel disease — the leading cause of obesity-related death.
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Complications
Carpal Tunnel Syndrome and Obesity
Carpal tunnel syndrome — numbness and tingling in the hand caused by pressure on a wrist nerve — occurs more often in people with obesity.
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Complications
Cataract and Obesity
A cataract is a clouding of the eye's natural lens, and carrying excess weight is linked with a higher chance of developing one - largely because obesity drives diabetes, inflammation and oxidative stress that damage the lens.
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Hormones
Catecholamines and Energy Expenditure
Catecholamines - adrenaline and noradrenaline - are the body's alertness and stress hormones; they raise energy expenditure, and medicines that block them can make weight harder to lose.
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Foundations
Cellular Senescence and Obesity
Cellular senescence is the accumulation of cells that stop dividing but stay alive and leak inflammatory signals - one way obesity behaves like accelerated ageing.
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Conditions
Cellulite and Weight Management
Cellulite is the dimpled appearance of the skin on the thighs, buttocks and hips that affects most women; excess weight makes it more noticeable, but it is not the same thing as obesity and weight loss does not always improve it.
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Complications
Cellulitis and Obesity
Cellulitis is a bacterial infection of the deep layers of the skin, and carrying excess weight raises the risk of getting it and of having it come back, mainly through skin folds, leg swelling and poorer lymphatic drainage.
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Medications
Cetilistat
A weight-loss medication that blocks fat absorption in the digestive system, designed to support weight management with fewer side effects.
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Hormones
Chemerin
Chemerin is an inflammatory signalling protein released by fat tissue that is elevated in obesity and linked to insulin resistance.
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Lifestyle
Chewing Rate and Satiety
Eating slowly and chewing thoroughly gives your body time to register fullness, helping you consume fewer calories without feeling deprived.
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Conditions
Childhood Obesity
Childhood obesity means a child carries substantially more body fat than is healthy for their age and sex, and because children are still growing, treatment focuses on family routines rather than restrictive diets.
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Procedures
Cholecystectomy After Rapid Weight Loss
Losing weight quickly makes gallstones far more likely, and removing the gallbladder is the most common operation performed after weight-loss surgery.
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Hormones
Cholecystokinin (CCK)
Cholecystokinin, or CCK, is a hormone released by the gut after eating.
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Conditions
Chronic Kidney Disease and Obesity
Chronic kidney disease is gradual loss of kidney function, and obesity is a major risk factor — weight loss can help slow its progression.
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Foundations
Chronic Low-Grade Inflammation
Carrying excess weight keeps the immune system mildly switched on, producing constant low-level inflammation that drives insulin resistance, fatty liver and heart disease.
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Conditions
Chronic Obstructive Pulmonary Disease and Obesity
Obesity is common alongside COPD and, despite an apparent survival advantage in smokers, it independently worsens breathlessness, exercise capacity and exacerbation risk.
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Psychological
Chronic Stress and Weight Gain
Long-running stress keeps cortisol and appetite hormones switched on, nudging food choices, sleep and fat storage in the wrong direction - it is physiology, not a failure of discipline.
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Complications
Chronic Venous Insufficiency and Obesity
Chronic venous insufficiency is a condition where leg veins struggle to return blood to the heart — and excess weight significantly worsens it.
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Nutrition
Chrononutrition
The science of how meal timing interacts with your body clock to influence metabolism and weight.
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Lifestyle
Circadian Rhythm and Weight
The relationship between your body's internal clock and weight regulation, showing how meal timing and sleep patterns affect metabolism and fat storage.
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Foundations
Clinically Significant Weight Loss
Clinically significant weight loss usually means losing about 5% of your starting weight — enough to measurably improve blood pressure, blood sugar and cholesterol.
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Psychological
Cognitive Behavioural Therapy (CBT)
Cognitive behavioural therapy, or CBT, is a structured form of talking therapy that helps people change the unhelpful thoughts and habits around food, eating and weight.
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Psychological
Cognitive Restructuring
Cognitive restructuring is a therapy technique that helps people recognise and replace unhelpful or extreme thoughts that can trigger overeating and derail weight loss.
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Lifestyle
Cold-Induced Thermogenesis
Cold-induced thermogenesis activates brown fat to burn calories for heat, offering a modest metabolic boost that can complement weight management efforts.
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Complications
Colorectal Cancer and Obesity
Bowel cancer is one of the cancers most strongly linked to excess weight, especially fat around the waist - and screening finds it early, when it is curable.
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Medications
Combination Appetite Therapy
Investigational injectable treatments combining an amylin analogue with a GLP-1 receptor agonist to target several appetite pathways at once.
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Body Composition
Conicity Index
The conicity index compares your waist measurement with the waist a cylinder of your own height and weight would have, so a higher number means fat is concentrated at the middle.
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Complications
Constipation and Weight Management
Constipation is more common in people carrying excess weight and is often worsened by low fibre, inactivity, some medicines and the appetite-suppressing injections - all of it manageable.
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Screening
Continuous Glucose Monitoring (CGM)
A small wearable sensor that tracks blood sugar every few minutes, revealing how different foods affect your glucose — useful for metabolic health and weight loss.
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Screening
Coronary Artery Calcium Score
A coronary artery calcium score is a low-dose CT scan that measures calcified plaque in the heart arteries, giving a single number that sharpens heart attack risk prediction beyond cholesterol and blood pressure.
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Medications
Corticosteroids and Weight Gain
Corticosteroid medicines such as prednisolone commonly cause weight gain and central fat redistribution by increasing appetite and changing where the body stores fat, even at modest doses.
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Hormones
Cortisol
Cortisol is the body's primary stress hormone, and chronically elevated levels can promote belly fat storage and increased appetite.
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Procedures
Cryolipolysis
A non-surgical fat freezing treatment that destroys fat cells in small, targeted areas of the body.
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Lifestyle
Culinary Medicine
An evidence-based approach that combines nutrition science with practical cooking skills to help patients make healthier food choices for long-term weight management.
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Conditions
Cushing's Syndrome
A hormonal disorder caused by prolonged exposure to high cortisol levels, leading to rapid central weight gain.
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Conditions
Cushing's Syndrome and Weight
Cushing's syndrome is a condition caused by too much cortisol, causing weight gain around the face, neck and abdomen.
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Lifestyle
Cycling for Weight Loss
Cycling burns energy at a rate comparable to brisk walking or better, while the bike carries the body weight - which makes it a practical option when knees or hips make walking and running difficult.
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Medications
Daily GLP-1 Injection
A daily injectable GLP-1 receptor agonist that reduces appetite and supports weight loss in adults with obesity. Prescription only, after medical assessment.
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Lifestyle
Daily Steps and Weight
Daily step counts are a simple, measurable way to track activity — any consistent increase over your baseline helps.
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Lifestyle
Dancing for Weight Loss
Structured dance programmes reduce body weight by about two kilograms and waist circumference by about three centimetres compared with no exercise, and they are unusually well tolerated because people keep turning up.
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Nutrition
DASH Diet
The DASH diet focuses on fruits, vegetables, whole grains, and low-fat dairy to reduce blood pressure and support healthy weight management.
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Foundations
De Novo Lipogenesis
The metabolic process where your liver converts excess carbohydrates into stored fat.
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Psychological
Delay Discounting
Delay discounting is the tendency to prefer a smaller reward now over a larger reward later - steep discounting makes immediate food hard to resist and long-term goals easy to abandon.
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Complications
Dental Caries and Obesity
Tooth decay and excess weight share the same drivers - frequent sugar, ultra-processed food and sweetened drinks - and people carrying extra weight are more likely to have active decay, particularly when blood sugar runs high.
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Conditions
Depression and Obesity
Depression and obesity have a bidirectional relationship — each increases the risk and severity of the other, requiring integrated treatment.
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Body Composition
Deuterium Dilution (Hydrometry)
Deuterium dilution measures the amount of water in the body after drinking a safe tracer, and from that calculates fat-free mass - it is the reference method for total body water.
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Foundations
DEXA Scan
A low-radiation imaging test that precisely measures bone density, body fat percentage, and lean muscle mass to guide weight management.
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Hormones
DHEA and Weight Management
DHEA is an adrenal hormone and a building block for testosterone and oestrogen; it is widely sold as a fat-burning supplement, but randomised trials have not shown meaningful weight loss.
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Conditions
Diabesity
The close link between obesity and type 2 diabetes, where losing weight is key to controlling blood sugar.
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Complications
Diabetic Retinopathy and Obesity
Diabetic retinopathy is diabetes damage to the light-sensing retina at the back of the eye - obesity and poor glucose control speed it up, and it is a leading cause of preventable blindness in working-age adults.
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Procedures
Diastasis Recti Repair
When the abdominal muscles stay separated after pregnancy or major weight change, the midline can be repaired with sutures, usually during a tummy tuck, after physiotherapy has been tried.
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Foundations
Dietary Adherence and Weight Loss
How closely and how long someone sticks to a plan predicts weight loss better than which diet is chosen - most diets perform similarly when people can actually sustain them.
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Nutrition
Dietary Fibre
Dietary fibre is the indigestible part of plant foods that promotes fullness, supports gut health, and aids weight management.
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Nutrition
Dietary Protein
A key nutrient that preserves muscle, promotes fullness, and supports healthy weight loss.
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Psychological
Dietary Restraint
Dietary restraint is consciously limiting food intake to control weight — flexible restraint works, but very rigid restraint often backfires into craving and overeating.
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Medications
Diethylpropion
A short-term prescription appetite suppressant that helps jump-start weight loss by reducing hunger signals in the brain.
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Lifestyle
Digital Health Tools for Weight Loss
Apps, wearables, and telehealth can support weight loss through self-monitoring and accountability, especially when combined with professional medical guidance.
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Psychological
Disinhibited Eating
Disinhibited eating is the tendency to overeat or lose control around food once eating has begun, especially when tasty food, emotions or social settings lower normal restraint.
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Psychological
Disordered Eating
Disordered eating is a range of irregular eating behaviours — like chronic dieting, skipping meals, or binge-restrict cycles — that are not severe enough to be a formal eating disorder but still harm health.
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Psychological
Distress Tolerance
Distress tolerance is the ability to get through an uncomfortable moment - stress, boredom, anger, craving - without doing something to escape it immediately, such as eating.
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Medications
Diuretics and Weight Loss
Diuretics make the kidneys pass more salt and water, so the scale falls quickly - but that is fluid, not fat, and using them to lose weight is ineffective and can be dangerous.
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Conditions
Diverticular Disease and Obesity
Obesity is one of the strongest risk factors for diverticulitis and diverticular bleeding, and it also raises the chance that a flare will be severe.
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Lifestyle
Dog Walking and Weight Management
Walking the dog is a daily, low-effort way owners accumulate physical activity - and dog walkers are more likely to meet activity targets and less likely to have obesity.
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Medications
Dual GIP/GLP-1 Receptor Agonist
An injectable treatment acting on two gut-hormone pathways to reduce appetite and improve blood sugar control. Prescription only, after medical assessment.
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Complications
Dumping Syndrome
Dumping syndrome happens when food moves too quickly from the stomach into the small intestine, most often after weight-loss surgery.
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Procedures
Duodenal Mucosal Resurfacing (DMR)
A minimally invasive endoscopic procedure that renews the duodenal lining to improve the body's hormonal response to food and help control blood sugar.
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Procedures
Duodenal Switch
A combined restrictive and malabsorptive bariatric procedure that produces the greatest weight loss among all surgical options for severe obesity.
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Procedures
Duodenal-Jejunal Bypass Liner (EndoBarrier)
A removable intestinal sleeve placed by endoscopy that mimics gastric bypass hormone changes to reduce appetite and improve blood sugar.
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Conditions
Dyslipidaemia
An imbalance of blood fats — high bad cholesterol or triglycerides — that increases heart disease risk and often improves with weight loss.
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Screening
Eating Disorder Examination Questionnaire (EDE-Q)
The EDE-Q is a 28-item questionnaire that measures eating-disorder thinking and behaviour over the past four weeks, scoring restraint, eating concern, shape concern and weight concern.
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Nutrition
Eating Frequency
How many meals you eat per day matters less for weight than total caloric intake and food quality, though irregular patterns can affect appetite control.
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Lifestyle
Eating Out Healthy
Eating out — hawker centres, food courts and restaurants — is part of daily life in Singapore. Ordering well is a learnable skill.
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Lifestyle
Eating Rate
The speed at which you eat — faster eating is linked to higher calorie intake and weight gain because the brain needs about 20 minutes to register fullness.
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Body Composition
Ectopic Fat
Ectopic fat is fat stored in organs where it does not belong — such as the liver, pancreas and muscle — and it is closely linked to insulin resistance and metabolic disease.
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Screening
Edmonton Obesity Staging System (EOSS)
The Edmonton Obesity Staging System, or EOSS, is a way for doctors to grade obesity based on how it affects your health and daily life, rather than just your BMI.
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Screening
Electrocardiogram (ECG)
An ECG records the heart's electrical rhythm in about five minutes; it is a standard part of the checks before weight-loss surgery or some medicines because obesity strains the heart and can mask problems.
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Psychological
Emotion Regulation and Weight Management
Emotion regulation is the set of skills you use to notice, name and manage feelings without turning to food, and people who find this harder tend to eat more in response to stress, boredom or low mood.
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Psychological
Emotional Eating
Using food to cope with emotions rather than physical hunger.
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Foundations
Endocrine Disruptors (Obesogens)
Chemicals in some plastics, pesticides and everyday products that can disrupt hormones and promote fat storage — part of the obesogenic environment.
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Complications
Endometrial Cancer and Obesity
Cancer of the womb lining is the cancer most strongly linked to excess weight, because fat tissue makes extra oestrogen - and losing weight lowers that risk.
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Procedures
Endoscopic Gastric Remodelling
A non-surgical, incisionless procedure that reshapes the stomach through an endoscope to reduce its capacity and support weight loss.
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Procedures
Endoscopic Sleeve Gastroplasty
A non-surgical, incisionless weight-loss procedure that reduces stomach size using an endoscope and internal sutures.
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Foundations
Energy Balance
The fundamental principle of weight management describing the relationship between calories consumed and calories burned.
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Foundations
Energy Density
Energy density is the number of calories per gram of food — choosing lower-density foods helps you feel full while controlling calorie intake.
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Foundations
Energy Flux
Energy flux is the rate of energy turnover in your body — high flux supports better weight control and metabolic health.
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Foundations
Energy Homeostasis
Energy homeostasis is your body’s system for balancing the energy you take in from food with the energy you burn through daily activity and metabolism.
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Procedures
Enhanced Recovery After Bariatric Surgery
Enhanced recovery after bariatric surgery is a standardised set of measures before, during and after the operation that speeds recovery and reduces complications without increasing readmissions.
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Lifestyle
Environmental Design for Weight Loss
The practice of arranging your surroundings to make healthy eating and activity choices the easiest and most natural option.
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Foundations
Epigenetics of Obesity
Epigenetics describes chemical marks that switch genes on or off without changing the genetic code, and in weight regulation these marks respond to early nutrition, stress, sleep and activity.
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Screening
Epworth Sleepiness Scale
The Epworth Sleepiness Scale is a simple questionnaire that measures how likely you are to doze off in everyday situations, helping to screen for sleep disorders like sleep apnoea.
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Complications
Erectile Dysfunction and Obesity
Erectile dysfunction is significantly more common in men with obesity, and weight loss can meaningfully improve erectile function.
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Body Composition
Essential Fat
Essential fat is the small amount of fat the body needs to function - about 3 to 5 per cent of body weight in men and 8 to 12 per cent in women - and going below it harms hormones and bone.
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Body Composition
Ethnic Differences in Body Composition
At the same body mass index, people of Chinese, Malay and South Asian ancestry tend to carry more body fat than people of European ancestry, which is why Singapore uses the lower BMI action points of 23 and 27.5.
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Complications
Excess Skin After Weight Loss
Excess skin, also called skin laxity, is loose, stretched skin that remains after substantial weight loss and does not tighten back on its own once the fat beneath it is gone.
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Psychological
Executive Function and Weight Management
Executive function is the brain's planning and self-control system — when it is weaker, resisting cravings and sticking to healthy routines gets harder, but these skills can be trained.
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Medications
Exenatide
The first approved GLP-1 receptor agonist — a twice-daily injection that improves blood sugar and supports weight loss.
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Lifestyle
Exercise Physiology
How physical activity affects body weight, metabolism, and health.
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Lifestyle
Exercise Snacking
Short, 1–2 minute bursts of vigorous activity spread throughout the day to improve fitness and metabolism.
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Complications
Exertional Dyspnoea and Obesity
Exertional dyspnoea is breathlessness on activity; in obesity fat loading of the chest wall lowers resting lung volumes and roughly doubles the oxygen cost of breathing, and moderate weight loss measurably improves both.
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Psychological
External Eating
External eating is eating in response to outside triggers such as the sight or smell of food, rather than because of true hunger.
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Body Composition
Extracellular Water (ECW)
Extracellular water is the fluid outside your cells - blood plasma and the fluid between tissues - and it makes up a larger share of total body water with inflammation, oedema or excess fat.
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Complications
Faecal Incontinence and Obesity
Faecal incontinence is involuntary leakage of stool - an under-reported consequence of excess weight and pelvic floor strain that is worth asking about.
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Complications
Falls and Obesity
People carrying excess weight fall more often, not less - weaker balance, muscles that are relatively weak for the load they carry, painful joints and nerve damage all contribute, and the consequences of a fall are more serious.
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Screening
Fasting Blood Glucose
Fasting blood glucose is a blood test, taken after at least eight hours without food, that measures the sugar level in your blood and screens for diabetes and prediabetes.
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Screening
Fasting Insulin
A fasting insulin blood test measures the level of insulin in your blood after an overnight fast — a key early marker of insulin resistance.
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Body Composition
Fat Loss vs Weight Loss
Fat loss means reducing body fat specifically, while weight loss is any decrease on the scale — including water, glycogen and muscle — so the two are not the same thing.
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Body Composition
Fat Mass Index (FMI)
The fat mass index divides your total body fat by your height squared, giving a clearer picture of body fatness than BMI alone.
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Foundations
Fat-Free Mass
Everything in your body that is not fat — muscles, bones, organs, and water. Preserving it during weight loss is essential.
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Body Composition
Fat-Free Mass Index
The fat-free mass index (FFMI) shows how much lean tissue — muscle, bone and water — you carry relative to your height, like a BMI for your muscle.
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Complications
Fatigue and Obesity
Fatigue is one of the most common complaints in obesity - body fat is linked to physical tiredness even when depression is accounted for, and losing weight while training with weights has been shown to bring energy back.
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Conditions
Fatty Liver Disease
Accumulation of fat in liver cells, strongly associated with obesity.
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Psychological
Fear of Weight Regain
Fear of weight regain is persistent anxiety about putting weight back on after losing it, which can either drive very rigid eating or, paradoxically, trigger the very relapse a person fears.
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Screening
Ferritin and Iron Studies
Ferritin and iron studies measure the body's iron stores - and people with obesity, and anyone who has had bariatric surgery, are prone to low iron even when their diet looks adequate.
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Lifestyle
Festive Weight Gain
Festive seasons — Chinese New Year, Hari Raya, Deepavali and Christmas — bring rich food and sweet treats. The gain is small, real and preventable.
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Screening
FIB-4 Index (Liver Fibrosis Score)
FIB-4 is a four-number blood calculation that estimates liver scarring and is now the recommended first-line test for people with fatty liver or metabolic risk.
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Hormones
Fibroblast Growth Factor 21 (FGF21)
Fibroblast growth factor 21 (FGF21) is a hormone-like protein released mainly by the liver that helps regulate blood sugar, fat burning and energy balance.
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Screening
FibroScan
FibroScan is a quick and painless scan that measures fat and scarring in your liver using sound waves, similar to an ultrasound.
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Psychological
Financial Incentives for Weight Loss
Paying people for hitting weight-loss targets works well while the money runs - especially deposit contracts, where you risk your own cash - but the effect fades once the incentive stops.
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Foundations
Foetal Programming of Obesity
How maternal health during pregnancy can influence a child's lifelong obesity risk through epigenetic changes.
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Conditions
Food Addiction and Obesity
A pattern of compulsive overeating driven by the same brain reward pathways involved in substance addiction.
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Lifestyle
Food Cravings
Intense, selective urges to eat specific foods, driven by brain chemistry rather than true hunger.
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Screening
Food Frequency Questionnaire (FFQ)
A food frequency questionnaire lists foods and asks how often each is eaten over the past month or year; it captures usual diet but under-reports energy intake by about a fifth and is not a precise calorie count.
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Foundations
Food Insecurity and Obesity
Food insecurity is unreliable access to enough affordable nutritious food, and it is paradoxically linked with higher rates of obesity and type 2 diabetes.
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Nutrition
Food Labels and Weight Management
The skill of reading nutrition labels to make informed food choices that support weight loss goals.
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Psychological
Food Noise
The constant background mental chatter about food — cravings and food thoughts that are not true hunger; often silenced by GLP-1 medication.
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Lifestyle
Food Reward
The brain's pleasure and motivation response to eating, especially processed foods that can override fullness signals and drive overeating.
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Body Composition
Four-Compartment Model of Body Composition
The four-compartment model combines body weight, body volume, total body water and bone mineral to give the most accurate research measurement of body fat.
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Screening
FRAX (Fracture Risk Assessment)
FRAX is a free calculator developed by the World Health Organization that estimates your 10-year chance of a hip fracture or a major osteoporotic fracture.
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Complications
Frozen Shoulder and Obesity
Frozen shoulder is a painful stiffening of the shoulder capsule that builds up over months, and carrying excess weight - especially with diabetes or prediabetes - makes it more likely and often slower to settle.
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Nutrition
Fruits and Vegetables and Weight
Fruits and vegetables fill you up for very few calories, so eating more of them helps control appetite and supports gradual, lasting weight loss.
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Medications
Gabapentinoids and Weight Gain
Gabapentin and pregabalin, widely used for nerve pain, epilepsy and anxiety, cause weight gain in a substantial minority of users, and the risk rises with dose.
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Conditions
Gallstones
Hardened deposits of digestive fluid that form in the gallbladder — obesity and rapid weight loss both increase the risk.
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Screening
Gamma-Glutamyl Transferase (GGT)
GGT is a liver enzyme measured by a standard blood test - a raised level is often the first clue to fatty liver, and it tends to fall as you lose weight.
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Procedures
Gastric Artery Embolisation
Gastric artery embolisation is a newer, minimally invasive procedure in which tiny beads are used to reduce the blood supply to part of the stomach.
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Procedures
Gastric Balloon
A non-surgical weight loss procedure placing a soft balloon in the stomach.
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Procedures
Gastric Botox
An endoscopic procedure using botulinum toxin injections into the stomach to slow gastric emptying and reduce appetite.
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Procedures
Gastric Bypass
A surgical weight-loss procedure that reduces stomach size and reroutes the intestine, leading to significant and lasting weight loss.
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Procedures
Gastric Bypass Reversal
Reversal of a Roux-en-Y gastric bypass restores normal anatomy for a small minority of patients with intractable dumping, excessive weight loss, marginal ulceration or malabsorption, at substantially higher risk than the original operation.
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Procedures
Gastric Electrical Stimulation
An implanted pacemaker-like device that sends pulses to the stomach to promote fullness and delay emptying.
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Hormones
Gastric Inhibitory Polypeptide (GIP)
GIP is a gut hormone released after meals that helps the body manage sugar and store energy — and it is now a key target in modern weight-loss medication.
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Procedures
Gastric Plication
A reversible weight loss surgery that folds and stitches the stomach to reduce its size without removing tissue.
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Medications
Gastrointestinal Effects of Weight-Loss Medication
Weight-loss medications can cause stomach and bowel effects such as nausea, vomiting, constipation or oily stools — most are temporary and manageable.
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Foundations
Genetic Factors in Obesity
Your genes can influence how your body stores fat, controls appetite and responds to food, which is why some people gain weight more easily than others.
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Complications
GERD
A chronic acid reflux condition that is common with excess weight and often improves significantly with weight loss.
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Complications
Gestational Diabetes and Obesity
Gestational diabetes is diabetes first diagnosed during pregnancy — and carrying excess weight significantly raises the risk, for both mother and baby.
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Hormones
Ghrelin
The hunger hormone — stimulates appetite before meals.
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Medications
GLP-1 Medication
A prescription medication class that mimics the GLP-1 hormone to regulate appetite and blood sugar, used in weight management and type 2 diabetes.
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Medications
GLP-1 Receptor Agonists
A class of medications that mimic the GLP-1 hormone to regulate appetite and blood sugar.
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Hormones
Glucagon
Glucagon is a hormone that raises blood sugar by releasing stored energy, and it also helps regulate how much energy the body burns — a target of newer weight-loss medications.
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Nutrition
Glucomannan
Glucomannan is a natural soluble fibre from konjac root that expands in the stomach to help you feel full, sometimes used as a weight-loss supplement.
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Body Composition
Gluteofemoral Fat
Gluteofemoral fat is the fat stored on the hips, buttocks and thighs; it behaves differently from belly fat and is linked to a lower, not higher, metabolic risk.
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Nutrition
Glycaemic Index
A measure of how quickly foods raise blood sugar levels.
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Nutrition
Glycaemic Load
Glycaemic load measures how much a typical serving of food actually raises blood sugar — a more practical tool than glycaemic index alone.
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Nutrition
Glycemic Index
The glycemic index (GI) ranks carbohydrate foods by how quickly they raise blood sugar.
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Nutrition
Glycemic Load
Glycemic load (GL) combines the glycemic index of a food with the amount of carbohydrate you actually eat.
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Psychological
Goal Setting and Weight Loss
The way goals are set - specific, behavioural, reviewed regularly - changes how much weight people actually lose, because the goal shapes the daily choices.
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Conditions
Gout
A painful arthritic condition linked to high uric acid, where weight loss can significantly reduce the frequency of attacks.
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Lifestyle
Grazing
Grazing means eating small amounts of food repeatedly throughout the day, often without planning or even noticing.
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Psychological
Grief and Weight Change
Bereavement commonly changes eating and body weight in either direction - involuntary weight loss is well documented in the year after losing a spouse, while comfort eating and weight gain also occur.
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Hormones
Growth Differentiation Factor 15 (GDF15)
Growth differentiation factor 15 (GDF15) is a stress-signalling protein that suppresses appetite and is a leading target for next-generation weight-loss treatments.
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Hormones
Growth Hormone and Weight
Carrying excess weight blunts the body's natural growth hormone release — and losing weight restores it.
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Foundations
Gut Microbiome
The trillions of bacteria in your digestive system that influence metabolism, appetite, and weight regulation.
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Foundations
Gut-Brain Axis
The two-way communication network between your gut and brain that regulates hunger, fullness, and metabolism.
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Procedures
Gynaecomastia Surgery After Weight Loss
Male chest fullness after major weight loss is usually a mix of fat and glandular tissue, and surgery plus liposuction is often needed because glandular tissue does not shrink with dieting.
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Lifestyle
Habit Stacking
A behavioural technique that pairs a new healthy habit with an existing routine to make lifestyle changes easier and more sustainable.
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Complications
Haemorrhoids and Obesity
Obesity and abdominal obesity carry a modestly higher risk of haemorrhoids, most plausibly through raised pressure inside the abdomen and the constipation that often comes with a low-fibre diet.
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Complications
Hair Loss After Weight Loss
Temporary hair shedding, known as telogen effluvium, can occur two to four months after rapid weight loss or weight-loss surgery, and usually resolves once nutrition and weight stabilise.
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Body Composition
Handgrip Strength
Handgrip strength measures how hard you can squeeze — a simple test of overall muscle strength that predicts health better than muscle size alone.
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Screening
HbA1c (Glycated Haemoglobin)
A blood test that measures your average blood sugar over two to three months, a key marker of metabolic health during weight loss.
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Medications
hCG for Weight Loss
Human chorionic gonadotropin injections and drops are marketed for rapid weight loss, but controlled trials show no benefit beyond the severe calorie restriction given with them.
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Psychological
Health Belief Model and Weight Management
The Health Belief Model explains that whether someone acts on weight advice depends on perceived susceptibility, severity, benefits and barriers plus self-efficacy - and benefits and barriers predict behaviour best.
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Psychological
Health Literacy and Weight Management
Health literacy is the ability to find, understand and act on health information - when it is limited, weight plans fail for reasons that have nothing to do with motivation.
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Screening
Health Screening
Comprehensive medical check-up to assess weight-related health risks.
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Nutrition
Healthy Plate Method
The Healthy Plate method is a simple visual guide for balanced meals: fill half your plate with vegetables and fruit, a quarter with lean protein and a quarter with whole grains.
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Complications
Hearing Loss and Obesity
Obesity and the metabolic problems that travel with it are linked to a higher risk of hearing loss, because the delicate blood supply to the inner ear is easily damaged.
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Complications
Heart Failure and Obesity
Obesity raises the risk of heart failure and can worsen it — but meaningful weight loss is one of the most effective ways to improve symptoms and heart function.
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Complications
Heat Intolerance and Obesity
People carrying excess weight often feel hot sooner and tolerate heat less well, because body fat insulates, surface area is small relative to body mass, and sweating responds more sluggishly.
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Psychological
Hedonic Hunger
Hedonic hunger is the urge to eat for pleasure rather than for energy — triggered by the sight, smell or thought of tasty food, and it can override normal fullness signals.
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Complications
Hiatus Hernia and Obesity
A hiatus hernia is when part of the stomach slides up through the diaphragm into the chest - extra weight around the middle makes it far more likely and makes reflux worse.
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Complications
Hidradenitis Suppurativa and Obesity
Hidradenitis suppurativa is a chronic inflammatory skin condition with painful lumps and boils, and obesity makes it more likely and more severe.
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Nutrition
High-Fibre Diet
A high-fibre diet is rich in vegetables, fruit, whole grains, legumes and nuts — filling, slow-digesting and good for the gut.
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Lifestyle
High-Intensity Interval Training (HIIT)
HIIT alternates short bursts of intense exercise with rest — a time-efficient way to burn fat and boost metabolism.
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Nutrition
High-Protein Diet
A high-protein diet increases the share of daily energy from protein — meat, fish, eggs, legumes and dairy — which helps fullness and preserves muscle during weight loss.
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Screening
High-Sensitivity C-Reactive Protein (hs-CRP)
High-sensitivity C-reactive protein (hs-CRP) is a blood test that measures low-level inflammation, which is often quietly elevated in people living with obesity.
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Lifestyle
Hiking for Weight Loss
Hiking burns more calories than walking on flat ground, and because it feels like an outing rather than a workout, people tend to stick with it.
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Lifestyle
Holiday Weight Management
Holidays and festive seasons bring larger meals, rich foods and disrupted routines, and it is common to gain a little weight.
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Screening
HOMA-IR
HOMA-IR is a simple calculation from a fasting blood test that estimates how insulin-resistant your body is — a higher score is an early warning sign for diabetes and stubborn weight gain.
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Medications
Hormonal Contraceptives and Weight Gain
Most hormonal contraceptives do not cause meaningful weight gain; the clear exception is the three-monthly injectable progestogen, which is associated with slow, cumulative gain over years.
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Lifestyle
Hydration and Weight Management
How adequate water intake supports weight loss by boosting metabolism, reducing calorie intake, and replacing high-calorie beverages.
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Body Composition
Hydrostatic Weighing
Hydrostatic (underwater) weighing is the classic gold-standard method for measuring body fat by weighing a person under water.
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Complications
Hyperhidrosis and Obesity
Hyperhidrosis is sweating far beyond what the situation warrants; excess weight strongly increases the late-onset form and the damp skin folds it produces, even though it does not cause the classic teenage type.
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Conditions
Hyperinsulinaemia
A condition of chronically elevated blood insulin levels that promotes fat storage and complicates weight loss.
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Conditions
Hyperphagia
Abnormally intense and persistent hunger that contributes to weight gain and requires clinical evaluation.
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Conditions
Hypertension
High blood pressure — a common condition often linked to excess weight.
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Conditions
Hyperuricaemia and Obesity
Elevated blood uric acid is strongly linked to obesity and can lead to gout; weight loss helps lower uric acid levels naturally.
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Conditions
Hypogonadism and Obesity
Hypogonadism means the body produces too little of the sex hormone testosterone, and it is common in men who carry excess weight.
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Conditions
Hypothalamic Obesity
Weight gain caused by damage to the hypothalamus, the brain's hunger control centre, leading to relentless appetite and metabolic disruption.
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Conditions
Hypothyroidism
An underactive thyroid gland that slows metabolism and can contribute to weight gain and difficulty losing weight.
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Complications
Idiopathic Intracranial Hypertension (IIH)
Raised pressure inside the skull linked to obesity, causing headaches and vision problems that often improve with weight loss.
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Hormones
IGF-1
IGF-1 is a hormone produced mainly by the liver that drives growth and repair — obesity changes its levels, and sustained weight loss helps normalise them.
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Procedures
Ileal Transposition
Ileal transposition is an experimental metabolic operation that moves a segment of lower small bowel higher up so nutrients meet it sooner, triggering gut hormones that improve blood sugar and appetite.
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Psychological
Implementation Intentions
An implementation intention is an if-then plan that links a specific situation to a specific action, so the response is decided in advance instead of relying on willpower.
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Procedures
Incisional Hernia Repair After Bariatric Surgery
A bulge at a surgical scar or keyhole port after weight-loss surgery is a hernia, far more common after open operations, and is usually repaired with mesh once weight has stabilised.
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Medications
Incretin-Based Therapies
A class of medications that mimic gut hormones to lower blood sugar, suppress appetite, and promote significant weight loss.
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Hormones
Incretins
Incretins are gut hormones released after eating that help control blood sugar and appetite — GLP-1 is the best known.
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Screening
Indirect Calorimetry
Indirect calorimetry measures how much oxygen a person uses and carbon dioxide they produce, giving a measured resting metabolic rate and an indication of which fuels the body is burning.
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Conditions
Infections and Obesity
Obesity keeps the immune system mildly inflamed and blunts parts of its response, raising the risk and severity of several infections including pneumonia and wound infections.
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Conditions
Infertility and Obesity
Obesity can disrupt hormonal balance and ovulation in both men and women, but weight loss can significantly improve fertility.
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Hormones
Insulin
Insulin is a hormone made by the pancreas that moves sugar out of the blood into cells for energy, and tells the body to store excess energy as fat.
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Hormones
Insulin Resistance
A condition where cells do not respond well to insulin, driving weight gain.
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Medications
Insulin Therapy and Weight Gain
Insulin is the most effective glucose-lowering medicine but commonly adds 2 to 4 kilograms in the first year, through retained calories and defensive eating after low blood sugar.
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Nutrition
Intermittent Fasting
An eating pattern cycling between periods of eating and fasting.
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Psychological
Internalised Weight Bias
Internalised weight bias is what happens when a person absorbs the negative messages society holds about higher body weights and turns them on themselves, producing shame, self-blame and a sense of not deserving help.
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Screening
International Physical Activity Questionnaire (IPAQ)
The IPAQ estimates a person's weekly physical activity in MET-minutes and sorts them into low, moderate or high activity levels from walking, moderate and vigorous activity.
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Psychological
Interoceptive Awareness
Interoceptive awareness is the ability to notice and interpret internal body signals such as hunger, fullness and thirst, and it is often blunted in obesity and disordered eating.
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Complications
Intertrigo
Intertrigo is a red, irritated rash that forms where skin folds rub together and trap moisture, such as under the breasts, in the groin, or beneath the belly.
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Body Composition
Intracellular Water (ICW)
Intracellular water is the water held inside your body's cells - chiefly inside muscle - so it reflects how much lean tissue you carry, while water outside the cells rises with inflammation and fluid retention.
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Procedures
Intragastric Balloon
An intragastric balloon is a soft silicone balloon placed in the stomach through the mouth that takes up space, helping you feel full sooner and eat less.
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Psychological
Intuitive Eating
Eating guided by your body's natural hunger and fullness signals rather than strict diet rules.
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Hormones
Irisin
Irisin is a hormone released by muscles during exercise that helps convert energy-storing white fat into energy-burning beige fat.
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Complications
Iron Deficiency Anaemia and Obesity
Obesity raises the risk of iron deficiency even when iron intake is adequate, because chronic inflammation drives the hormone hepcidin to block iron absorption and lock iron away in stores.
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Procedures
Jejunoileal Bypass
A historical malabsorptive weight-loss surgery abandoned due to severe complications — a milestone in bariatric surgery evolution.
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Nutrition
Ketogenic Diet
A very low-carbohydrate, high-fat diet that induces ketosis, causing the body to burn fat for fuel.
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Screening
Kidney Function Tests (eGFR & Creatinine)
Kidney function tests measure how well your kidneys filter waste, using blood creatinine and the eGFR — a calculation of your filtration rate.
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Conditions
Kidney Stones and Obesity
Obesity and metabolic syndrome raise the risk of kidney stones, especially uric acid stones, and rapid weight loss or bypass surgery can increase calcium oxalate stone risk.
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Hormones
Kisspeptin and Obesity
Kisspeptin is the brain hormone that switches on the reproductive system, and excess weight disturbs its signalling, contributing to low testosterone, irregular periods and reduced fertility.
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Procedures
Laser Lipolysis
Laser lipolysis is a minimally invasive treatment that uses laser energy to heat and melt fat beneath the skin, which is then naturally removed by the body or gently…
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Body Composition
Lean Body Mass
Lean body mass is everything in your body except fat — muscle, bone, organs and water.
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Hormones
Leptin
The satiety hormone — regulates hunger and energy balance.
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Hormones
Leptin Resistance
Leptin resistance — the brain stops responding to the 'fullness' hormone leptin, so hunger stays high and metabolism slows even when fat stores are plentiful.
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Medications
Lipase Inhibitor
A prescription treatment that reduces how much dietary fat the body absorbs from food, used as part of medically supervised weight management.
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Conditions
Lipedema
Lipedema is a condition of abnormal fat distribution, almost always in women, causing painful symmetrical enlargement of the legs that does not respond to dieting.
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Screening
Lipid Accumulation Product (LAP)
The lipid accumulation product combines waist circumference and fasting triglycerides into a single number that flags excess central fat better than body mass index.
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Screening
Lipid Profile
A blood test measuring cholesterol and triglycerides — a key screening tool to assess heart disease risk during weight management.
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Conditions
Lipidema
A chronic condition causing painful, abnormal fat accumulation mainly in the legs and arms, often mistaken for simple obesity.
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Hormones
Lipocalin-2 (NGAL)
Lipocalin-2 is a protein released by fat, bone and immune cells that is raised in obesity and insulin resistance, while the bone-derived form signals the brain to suppress appetite through the melanocortin-4 receptor.
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Conditions
Lipodystrophy
A group of rare disorders causing abnormal fat distribution and severe metabolic complications from impaired fat storage.
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Conditions
Lipohypertrophy
Abnormal fat accumulation at insulin injection sites that can interfere with diabetes management and complicate weight loss efforts.
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Foundations
Lipolysis
The biological process of breaking down stored fat into usable energy, driven by a caloric deficit and regulated by hormones.
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Procedures
Liposuction
A cosmetic fat-removal procedure for body contouring — not a weight-loss treatment or obesity solution.
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Conditions
Lipotoxicity
The damaging effects of excess fat accumulation in organs like the liver, pancreas, and muscles.
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Medications
Lithium and Weight Gain
Lithium causes weight gain in a substantial minority of users, most of it in the first year or two, and although recent pooled averages are small the individual variation is wide.
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Screening
Liver Function Tests (LFTs)
Liver function tests are a group of blood tests that measure liver enzymes and proteins, used to check for fatty liver and other liver problems linked to excess weight.
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Screening
Liver Ultrasound
A liver ultrasound is the usual first test for fat in the liver - a bright, echogenic liver on the scan, which is very common with excess weight.
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Procedures
Liver-Shrinking Diet Before Bariatric Surgery
The liver-shrinking diet is the two to four week pre-operative eating plan, usually meal-replacement shakes plus a small low-carbohydrate meal, that reduces liver volume so weight-loss surgery is safer and easier to perform.
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Psychological
Locus of Control and Weight Management
Locus of control describes how far you believe your outcomes come from your own actions rather than luck or other people - and believing your choices matter is linked with sticking to a weight plan.
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Psychological
Loneliness and Obesity
Loneliness and social isolation are linked with higher rates of obesity and with poorer weight-loss results, because eating often substitutes for company and for calming stress.
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Medications
Lorcaserin
A selective serotonin receptor agonist that reduced appetite by activating satiety pathways, withdrawn in 2020 after long-term safety review.
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Complications
Low Back Pain and Obesity
Low back pain is more common and more disabling in people with obesity, and losing even a modest amount of weight can significantly improve it.
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Nutrition
Low-Carbohydrate Diet
A low-carbohydrate diet reduces the share of daily energy from carbohydrates — bread, rice, noodles and sugars — and increases the share from protein and fat.
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Nutrition
Low-Glycaemic Diet
A diet focused on foods that cause a slow, steady rise in blood sugar, helping with appetite control and sustained energy.
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Complications
Lymphoedema and Obesity
Lymphoedema is chronic swelling caused by fluid building up in body tissues; obesity can cause it directly and makes it worse.
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Nutrition
Macronutrients
The three main nutrients: carbohydrates, proteins, and fats — all essential for health.
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Procedures
Marginal Ulcer After Bariatric Surgery
A marginal ulcer is an ulcer at the join between the small stomach pouch and the intestine after gastric bypass; it usually heals with acid-suppressing medicine and is strongly linked to smoking, anti-inflammatory painkillers, diabetes and H. pylori.
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Body Composition
Marrow Adipose Tissue
Bone marrow contains fat as well as blood-forming cells - it increases in obesity, harms bone-building, and changes in the first years after weight-loss surgery.
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Complications
MASLD (Metabolic Dysfunction-Associated Steatotic Liver Disease)
MASLD is the current name for fat accumulating in the liver in a person who also has at least one feature of metabolic ill health, such as a large waist, high blood pressure, high blood sugar or abnormal cholesterol.
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Procedures
Mastopexy (Breast Lift) After Weight Loss
Breasts that have lost volume and dropped after major weight loss usually need a lift rather than an implant, because stretched skin may not support a prosthesis.
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Screening
Matsuda Index
The Matsuda index is a measure of whole-body insulin sensitivity calculated from the glucose and insulin readings taken during a two-hour glucose tolerance test, so it shows how well the body responds to insulin after a sugar load.
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Medications
Mazindol
An appetite suppressant that works on the brain's hunger control centre, historically used for short-term weight management in resistant cases.
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Medications
MC4R Agonist Therapy
An injectable treatment for severe obesity caused by specific rare genetic conditions affecting appetite regulation.
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Lifestyle
Meal Prepping
A structured food preparation strategy that makes healthy eating convenient by preparing meals in advance.
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Nutrition
Meal Replacement Products
Meal replacement products are shakes, bars or soups designed to replace a full meal with a controlled number of calories and nutrients.
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Procedures
Medical Tourism for Weight Loss Surgery
Travelling abroad for weight-loss surgery costs far less, but reported complication rates among patients who return home for care are several times higher than those of local accredited programmes, and aftercare is harder to arrange.
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Medications
Medication-Induced Weight Gain
Weight gain caused by common prescription drugs — some antidepressants, steroids, antipsychotics and more — often manageable by switching to weight-neutral alternatives.
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Nutrition
Mediterranean Diet
A balanced, evidence-based eating pattern rich in vegetables, olive oil, fish, and whole grains.
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Nutrition
Medium-Chain Triglycerides
Fats that bypass normal digestion, providing quick energy and modestly boosting metabolism and satiety.
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Hormones
Melatonin
Melatonin is the hormone that signals night-time to your body clock; disrupted melatonin patterns are linked to poor sleep, and short sleep is linked to weight gain.
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Conditions
Menopause and Weight Gain
Weight gain driven by declining oestrogen during menopause — shifts fat storage to the abdomen and slows metabolism.
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Hormones
Menopause and Weight Gain
Many women gain weight around menopause, particularly around the abdomen — hormonal changes shift where fat is stored.
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Body Composition
Metabolic Adaptation
The body's natural slowing of metabolism in response to weight loss.
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Foundations
Metabolic Flexibility
The body's ability to switch between burning carbohydrates and fats — poor flexibility is linked to weight gain and insulin resistance.
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Foundations
Metabolic Health
How well your body regulates blood sugar, cholesterol, and blood pressure, a fuller measure of health than weight alone.
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Conditions
Metabolic Syndrome
A cluster of conditions that increase risk of heart disease, stroke, and diabetes.
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Foundations
Metabolically Healthy Obesity
Metabolically healthy obesity describes a high body mass index without the usual metabolic abnormalities, and it is a temporary state of lower risk rather than a harmless one.
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Medications
Metformin
A diabetes medication that can support modest weight loss by improving insulin sensitivity and reducing liver sugar production.
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Medications
Metreleptin
Metreleptin is an injectable man-made form of leptin approved for generalised lipodystrophy, where the body cannot produce enough leptin - it is not a treatment for common obesity.
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Screening
Microalbuminuria
Microalbuminuria is a small amount of the protein albumin leaking into the urine - the earliest sign that obesity, high blood pressure or diabetes is straining the kidney filters, and it is detected with a simple urine test.
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Nutrition
Micronutrient Deficiencies in Obesity
People with obesity can still lack important vitamins and minerals such as vitamin D, iron, and vitamin B12.
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Complications
Migraine and Obesity
Obesity raises the risk and severity of migraines; losing 5-10% of body weight can reduce how often migraine attacks occur.
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Psychological
Mindful Eating
The practice of paying full attention to eating experiences to recognise hunger cues and break emotional eating patterns.
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Psychological
Mindless Eating
Mindless eating is eating on autopilot - in front of a screen, while driving or standing at the counter - so that portions go unnoticed, fullness signals are missed and more is eaten than intended.
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Procedures
Mini Gastric Bypass (OAGB)
A simplified weight loss surgery using a single connection to reduce stomach size and calorie absorption.
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Medications
Mirtazapine and Weight Gain
Mirtazapine is an antidepressant that commonly causes weight gain, typically a few kilograms in the first weeks to months of treatment, driven by increased appetite and its effects on histamine and serotonin signalling.
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Complications
Mobility Disability and Obesity
Mobility disability means difficulty walking a few hundred metres, climbing stairs or rising from a chair, and excess weight raises the risk through joint load, reduced fitness and reduced strength relative to body mass.
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Conditions
Monogenic Obesity
Monogenic obesity is severe early-onset obesity caused by a mutation in a single gene, most often within the leptin-melanocortin appetite pathway.
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Lifestyle
Morning vs Evening Exercise
Morning exercise may enhance fat burning and consistency, while evening exercise may boost strength — the best time is the one you can keep to.
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Psychological
Motivational Interviewing
Motivational interviewing is a proven counselling style that helps people find their own reasons to change — a key part of long-lasting weight loss.
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Lifestyle
Movement Breaks
Short bursts of light activity taken throughout the day to break up long periods of sitting.
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Screening
MRI-PDFF (Proton Density Fat Fraction)
MRI-PDFF is a magnetic resonance scan that measures the percentage of fat inside the liver without a biopsy, giving a precise number that can be tracked over time.
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Complications
Multiple Sclerosis and Obesity
Obesity in the teenage years roughly doubles the later risk of multiple sclerosis, and carrying extra weight with MS adds fatigue, pain and disability on top of the disease itself.
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Body Composition
Muscle Loss During Weight Loss
Muscle loss during weight loss is the unintentional loss of lean body mass that occurs when dieting, especially with rapid weight loss, low protein intake or no resistance exercise.
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Body Composition
Muscle Mass
Muscle mass is the amount of skeletal muscle in your body — the tissue that burns energy at rest and is most at risk during rapid weight loss.
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Body Composition
Muscle Quality
Muscle quality describes how well muscle performs for its size — the strength and function a person gets from each unit of muscle mass.
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Nutrition
Mushrooms and Weight Management
Mushrooms fill a plate for very few calories, so swapping some meat for them lowers the energy of a meal without making it feel smaller.
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Hormones
Myostatin
Myostatin is a signal released by muscle that limits how much muscle you can build; training and protein lower it, and blocking it is being tested as a way to lose fat without losing muscle.
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Body Composition
Myosteatosis
Myosteatosis is the buildup of fat inside muscle tissue, making muscles look bigger but weaker and less responsive to insulin.
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Medications
Naltrexone
An opioid blocker that, combined with bupropion, helps reduce food cravings and support medically supervised weight loss.
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Medications
Naltrexone/bupropion (combination)
A prescription combination medication (naltrexone/bupropion) that reduces hunger and food cravings for weight management.
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Hormones
Natriuretic Peptides and Obesity
Natriuretic peptides are heart hormones that flush out salt and water and also help fat cells burn energy; levels are lower in obesity, which can mislead heart-failure testing.
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Lifestyle
NEAT (Non-Exercise Activity Thermogenesis)
The calories burned through everyday non-exercise activities like walking, standing, and household chores.
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Screening
Neck Circumference
Neck circumference is a simple tape measure of the upper airway that helps screen for sleep apnoea and metabolic risk.
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Hormones
Nesfatin-1
Nesfatin-1 is a signalling molecule made in the brain, gut and fat tissue that reduces appetite; levels tend to be lower in people with obesity, and it is one of the body's satiety brakes.
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Hormones
Neuropeptide Y (NPY)
Neuropeptide Y is one of the brain strongest appetite-stimulating signals, released when energy stores fall, and it rises further after weight loss, which helps explain hunger during weight maintenance.
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Conditions
Night Eating Syndrome
A condition where a person consumes a large portion of daily calories after dinner or during the night.
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Lifestyle
Night Shift and Weight
Night-shift work disrupts the body clock, and shift workers gain weight more easily — eating at night, less sleep and altered hunger hormones all contribute.
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Complications
Nocturia and Obesity
Nocturia is waking at night to pass urine - common in people carrying excess weight, and frequently improved by losing it.
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Conditions
Non-Alcoholic Steatohepatitis (NASH)
The inflammatory, progressive form of fatty liver disease that can lead to cirrhosis — weight loss of 7–10% is the most effective treatment.
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Psychological
Non-Scale Victories (NSVs)
Non-scale victories, or NSVs, are signs of progress that do not involve the number on the scale.
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Body Composition
Normal-Weight Obesity
Normal-weight obesity means a healthy BMI but excess body fat and low muscle — a pattern that still carries metabolic risk.
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Nutrition
Nutri-Grade Labelling
Nutri-Grade is the mandatory Singapore nutrition label for drinks, grading beverages A to D by sugar and saturated fat content and banning advertising of the least healthy grade.
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Nutrition
Nutrient Density
Nutrient density describes how many beneficial nutrients a food contains relative to its calories — nutrient-dense foods give you more vitamins, minerals and fibre per calorie.
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Foundations
Nutrient Sensing Pathways (mTOR and AMPK)
mTOR and AMPK are the sensors that tell a cell whether nutrients are plentiful or scarce, and in the brain the same machinery reads leptin, insulin, glucose and amino acid signals and adjusts appetite accordingly.
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Nutrition
Nuts and Weight Management
Nuts are energy dense but regular eaters gain less weight over time, because they increase fullness and a meaningful share of their fat is never absorbed.
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Conditions
Obesity
A chronic medical condition defined by excessive body fat that increases health risks.
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Conditions
Obesity and Cognitive Decline
Midlife obesity is linked to a higher risk of cognitive decline and dementia later in life, probably through vascular damage, insulin resistance, inflammation and sleep apnoea.
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Complications
Obesity and Dementia Risk
Carrying excess weight in midlife is linked to a higher risk of dementia decades later, most likely through vascular, metabolic and inflammatory pathways rather than through fat itself.
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Conditions
Obesity and Osteoporosis
Extra weight was once thought to protect bone, but obesity plus rapid weight loss or weight-loss surgery can weaken bones and increase fracture risk.
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Conditions
Obesity and Pregnancy
Carrying excess weight during pregnancy can raise the risk of complications such as gestational diabetes, high blood pressure and a larger baby.
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Complications
Obesity and Stroke
Carrying excess weight raises the risk of ischaemic stroke through hypertension, atrial fibrillation, insulin resistance and inflammation, and it also worsens recovery afterwards.
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Foundations
Obesity as a Chronic Disease
Obesity is a long-term medical condition, not a matter of willpower.
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Foundations
Obesity Classification (Class I, II, III)
A BMI-based grading of obesity severity that guides which weight-loss treatments are appropriate.
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Conditions
Obesity Hypoventilation Syndrome
A serious breathing disorder in people with severe obesity where excess weight restricts lung function.
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Conditions
Obesity in Older Adults
After 65 the same body mass index carries different meaning, because muscle mass has already fallen - weight loss helps function only when it protects muscle and bone.
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Foundations
Obesity Paradox
The observation that overweight or mildly obese patients with certain chronic diseases may have better survival.
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Foundations
Obesity Phenotypes
Obesity phenotypes are clinically distinct patterns of obesity - such as hungry brain, emotional hunger, slow burn and hungry gut - which respond differently to treatment.
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Conditions
Obesity-Related Glomerulopathy
Kidney damage caused by excess weight, leading to protein leakage and progressive decline in kidney function.
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Foundations
Obesogenic Environment
A setting that promotes weight gain through easy access to unhealthy food and barriers to physical activity.
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Hormones
Obestatin
Obestatin is a stomach hormone linked to appetite and fullness — the lesser-known partner of ghrelin, the 'hunger hormone'.
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Hormones
Oestrogen and Fat Storage
Oestrogen influences where your body stores fat — and when levels fall, as after menopause, fat shifts from hips and thighs toward the belly.
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Nutrition
Omega-3 Fatty Acids and Weight
Healthy fats found in fish and certain plant oils that reduce inflammation and support metabolism.
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Hormones
Omentin
Omentin is an anti-inflammatory adipokine produced mainly by visceral fat tissue; its levels fall in obesity and rise with better insulin sensitivity.
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Medications
Opioids and Weight Gain
Long-term opioid medicines are a recognised and often overlooked cause of weight gain, largely through suppression of the sex hormone axis and changes in food reward, with methadone and buprenorphine also producing measurable increases in body fat.
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Medications
Oral GLP-1 Tablet
A daily oral GLP-1 receptor agonist tablet used in type 2 diabetes and, where clinically appropriate, weight management. Prescription only.
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Screening
Oral Glucose Tolerance Test
The oral glucose tolerance test (OGTT) checks how well your body handles sugar after a glucose drink — the most reliable way to catch prediabetes and diabetes early.
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Screening
Oral Glucose Tolerance Test (OGTT)
The oral glucose tolerance test (OGTT) measures how well your body handles a standard dose of sugar over two hours — the gold standard for diagnosing prediabetes and diabetes.
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Procedures
Oral Hydrogel for Weight Management
An oral hydrogel is a capsule taken with a large glass of water before meals that swells into a gel in the stomach, adding volume and fullness; it is a non-systemic device used alongside diet and exercise.
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Foundations
Orexigenic Signals
The body's natural eat-more messages — hormones and brain chemicals that drive hunger and food intake.
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Hormones
Orexin
Orexin is a brain chemical that regulates wakefulness and appetite, linking poor sleep with increased hunger and weight gain.
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Medications
Orforglipron
An oral GLP-1 receptor agonist in development that mimics natural hunger-regulating hormones without injections.
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Medications
Orlistat
Orlistat is a weight-loss medication that blocks the absorption of about a third of the fat you eat, helping create the calorie deficit needed to lose weight.
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Psychological
Orthorexia Nervosa
Orthorexia nervosa is an unhealthy obsession with eating only foods a person considers pure or healthy, to the point that it harms their wellbeing and daily life.
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Complications
Osteoarthritis
Joint degeneration worsened by excess weight, particularly in knees and hips.
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Hormones
Osteocalcin
Osteocalcin is a protein made by bone-building cells that also behaves like a hormone, improving insulin sensitivity and energy use - levels are lower in obesity and type 2 diabetes.
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Screening
Overnight Pulse Oximetry
Overnight pulse oximetry is a simple test worn on the finger during sleep that measures blood oxygen and heart rate, and the dips it records are a first-line screen for obstructive sleep apnoea.
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Foundations
Oxidative Stress and Obesity
Oxidative stress is the imbalance between damaging free radicals and the body's antioxidant defences; obesity raises it and weight loss brings it back down.
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Medications
Oxyntomodulin
A gut hormone that reduces appetite and is being developed as a new injectable treatment for obesity.
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Hormones
Oxytocin and Appetite Regulation
Oxytocin is best known for labour and bonding, but it also acts on appetite circuits: a single intranasal dose reduced how much healthy men ate at a test meal by about 122 kilocalories.
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Nutrition
Paleo Diet
The paleo diet centres on foods presumed available to early humans — lean meat, fish, eggs, vegetables, fruit, nuts and seeds — while excluding grains, legumes, dairy, refined sugar and processed food.
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Body Composition
Pancreatic Fat Deposition
Fat can accumulate inside the pancreas as well as the liver, and pancreatic fat is closely linked to type 2 diabetes and to loss of insulin-producing beta cell function.
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Complications
Pancreatitis and Obesity
Pancreatitis is inflammation of the pancreas; obesity raises the risk of both gallstone-related and fat-triggered forms, and makes attacks more severe.
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Procedures
Panniculectomy
A panniculectomy is surgery to remove the hanging apron of excess skin and fat over the lower belly that can remain after major weight loss.
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Conditions
PCOS
Polycystic Ovary Syndrome — a hormonal disorder common in women, linked to weight.
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Hormones
Peptide YY (PYY)
A gut hormone released after eating that signals fullness to the brain and reduces appetite.
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Psychological
Perfectionism and Weight Management
Perfectionism means holding yourself to all-or-nothing standards, so one slip can feel like total failure and derail an otherwise good weight-loss plan.
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Body Composition
Pericardial Adipose Tissue
Pericardial adipose tissue is the fat sitting directly on and around the heart, and it behaves harmfully like visceral fat rather than like fat under the skin.
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Complications
Periodontal Disease and Obesity
Obesity raises the risk and severity of gum disease, and the two conditions share inflammation and insulin resistance, so treating one helps the other.
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Complications
Peripheral Neuropathy and Obesity
Peripheral neuropathy is damage to the nerves supplying the feet and hands, causing numbness, burning or tingling - obesity, prediabetes and diabetes are its biggest drivers.
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Body Composition
Perivascular Adipose Tissue
Perivascular adipose tissue is the fat wrapped around blood vessels; far from inert padding, it releases signals that affect how arteries relax, stiffen and become inflamed.
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Foundations
Personal Fat Threshold
The personal fat threshold is the idea that each person has a limit of fat storage — once exceeded, fat spills into organs and can trigger type 2 diabetes.
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Body Composition
Phase Angle
Phase angle is a number measured during a body composition scan that reflects the health of your body’s cells and muscles.
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Medications
Phendimetrazine
A short-term prescription appetite suppressant used as part of a medically supervised weight loss programme.
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Medications
Phentermine
A short-term prescription appetite suppressant used alongside diet and exercise for medically supervised weight loss.
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Screening
PHQ-9 (Patient Health Questionnaire-9)
The PHQ-9 is a nine-question depression screen scored out of 27 - a score of 10 or more detects major depression with about 88% sensitivity and specificity - and it is used routinely in weight-management and bariatric assessment.
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Complications
Pilonidal Disease and Obesity
Pilonidal disease is a painful hair-containing sinus in the cleft between the buttocks; being overweight raises the risk modestly but raises the risk of recurrence after surgery more usefully.
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Screening
Pittsburgh Sleep Quality Index (PSQI)
The Pittsburgh Sleep Quality Index (PSQI) is a standard questionnaire that measures sleep quality over the past month and helps screen for sleep problems that can affect weight.
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Nutrition
Plant-Based Diet
A plant-based diet emphasises vegetables, fruit, whole grains, legumes, nuts and seeds, with little or no animal food.
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Nutrition
Plant-Based Diets for Weight Management
Eating patterns centred on plant foods that support weight loss through lower calorie density and higher satiety.
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Complications
Plantar Fasciitis and Obesity
Plantar fasciitis — a sharp pain under the heel, worst with the first steps in the morning — is strongly linked to carrying extra weight.
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Screening
Polysomnography
Polysomnography is an overnight sleep study that records breathing, oxygen levels and brain activity to diagnose conditions such as obstructive sleep apnoea.
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Hormones
POMC (Pro-Opiomelanocortin)
POMC is the parent molecule that appetite-controlling brain cells cut into smaller signals - including the one that tells you to stop eating - and when that pathway fails, severe early-onset obesity follows.
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Body Composition
Ponderal Index
The ponderal index divides weight by height cubed, giving a body-size number that is less distorted by height than BMI, though it still cannot tell fat from muscle.
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Lifestyle
Portion Control
Managing the amount of food you eat at each meal, a proven behavioural strategy for reducing calorie intake.
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Lifestyle
Portion Distortion
Portion distortion is the growing tendency to see oversized servings as normal, which makes it easy to eat far more calories than we realise.
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Conditions
Post-Bariatric Hypoglycaemia
A complication of weight loss surgery where blood sugar drops too low after eating.
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Conditions
Postpartum Weight Retention
Postpartum weight retention is the weight still carried above pre-pregnancy weight months after birth, and it is one of the strongest predictors of long-term weight gain in women.
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Conditions
Prader-Willi Syndrome
A rare genetic disorder causing constant extreme hunger, slow metabolism, and lifelong weight management challenges.
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Medications
Pramlintide
A synthetic amylin analogue injection that slows gastric emptying and promotes satiety.
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Complications
Pre-eclampsia and Obesity
Pre-eclampsia is a serious pregnancy complication marked by high blood pressure and protein in the urine, and obesity significantly increases the risk of developing it.
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Nutrition
Prebiotics and Weight Management
Non-digestible fibres that feed beneficial gut bacteria and may support weight management through the gut-brain axis.
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Conditions
Prediabetes
Blood sugar levels higher than normal but not yet diabetic — a critical window where weight loss can reverse the trend.
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Hormones
Preptin
Preptin is a small hormone made by the pancreas and released together with insulin that helps build bone and influences glucose handling; levels are raised in obesity and insulin resistance.
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Medications
Prescription Appetite Suppressant
A short-term prescription treatment that reduces hunger signals, used under medical supervision as part of a wider weight management plan.
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Procedures
Prescription Digital Therapeutics
App-based therapy programmes prescribed by doctors to support weight loss through behavioural change.
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Procedures
Primary Obesity Surgery Endolumenal (POSE)
A non-surgical, incisionless endoscopic procedure that reduces stomach capacity to help you feel full sooner.
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Nutrition
Probiotics and Weight Management
Beneficial live bacteria that support gut health and may aid weight management by influencing appetite hormones.
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Hormones
Prolactin and Weight Gain
Prolactin is a hormone that, when present at abnormally high levels, can cause weight gain and make weight loss difficult.
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Nutrition
Protein Leverage Hypothesis
The idea that the body overeats calories from fats and carbs to meet a fixed daily protein target.
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Nutrition
Protein Timing
The strategic distribution of protein intake across meals to preserve muscle mass and enhance satiety.
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Foundations
Protein Turnover and Weight Management
Protein turnover is the daily balance between building and breaking down muscle protein - the balance that decides how much of your weight loss comes from fat rather than muscle.
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Complications
Psoriasis and Obesity
Obesity fuels the inflammation behind psoriasis, making it more common and harder to treat — weight loss measurably improves the skin.
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Psychological
Psychological Flexibility and Weight Management
Psychological flexibility is the capacity to notice difficult thoughts, urges and feelings without being driven by them, and to keep acting in line with what matters - the skill that lets a person ride out a craving and still choose their plan.
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Nutrition
Pulses and Weight Management
Pulses are the edible seeds of legumes such as lentils, chickpeas and dried beans, and their protein and fibre content makes them unusually filling for their calories.
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Procedures
Radiofrequency Body Contouring
Radiofrequency body contouring is a non-surgical treatment that uses heat energy to reduce stubborn pockets of fat and tighten skin.
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Complications
Refeeding Syndrome
A dangerous shift in blood salts that can occur when food is reintroduced too quickly after severe calorie restriction — why medical supervision matters on very low-calorie diets.
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Psychological
Relapse Prevention
Relapse prevention is the pre-planned set of skills that keeps weight off: spotting high-risk situations early, having a specific response ready, and treating a slip as information rather than failure.
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Body Composition
Relative Fat Mass (RFM)
Relative fat mass (RFM) is a simple formula using your height and waist size that estimates body fat percentage without any special equipment.
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Psychological
Resilience and Weight Management
Resilience is the ability to keep going and restart after setbacks; it supports weight management, but research warns it is not the willpower test patients fear it is.
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Lifestyle
Resistance Training
Building muscle through exercises like weight lifting, boosting metabolism and supporting sustainable weight loss.
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Lifestyle
Resistance Training and Weight Loss
Resistance training — weights, bands or body-weight exercises — preserves muscle during weight loss, so more of what you lose is fat.
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Nutrition
Resistant Starch
A carbohydrate that resists digestion, feeding beneficial gut bacteria to improve blood sugar control and appetite regulation.
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Hormones
Resistin
Resistin is an inflammatory protein that is elevated in obesity and linked to insulin resistance and type 2 diabetes.
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Foundations
Respiratory Quotient
Reveals whether your body is burning carbohydrates or fats for energy, helping tailor your weight management plan.
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Foundations
Resting Metabolic Rate (RMR)
The energy your body uses at complete rest — understanding it helps create personalised weight management plans.
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Medications
Retatrutide
An investigational triple-hormone agonist that achieved substantial body weight loss in clinical trials.
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Hormones
Retinol-Binding Protein 4 (RBP4)
Retinol-binding protein 4 is the carrier protein for vitamin A, released by the liver and by fat cells, that rises in obesity and insulin resistance and is one of the molecular links between excess fat and type 2 diabetes.
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Procedures
Revisional Bariatric Surgery
A second weight loss operation to address inadequate weight loss or weight regain after initial bariatric surgery.
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Nutrition
Rice and Weight Management
Rice is the staple of Singaporean eating, and it is the portion, the type and what comes with it that decides its effect on weight and blood sugar.
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Medications
Rimonabant
The first CB1 receptor antagonist for weight loss — withdrawn due to psychiatric side effects but historically significant.
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Procedures
Robotic Bariatric Surgery
Weight-loss procedures performed with a surgeon-controlled robotic platform for enhanced precision and smaller incisions.
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Lifestyle
Rock Climbing for Weight Loss
Rock climbing is an interval-style, whole-body workout that burns energy at a rate comparable to running while building grip, back and core strength.
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Lifestyle
Running for Weight Loss
Running burns more energy per minute than almost any common exercise, but trials of running or aerobic training without dietary change produce only about two kilograms of weight loss over several months, because appetite and daily activity compensate.
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Procedures
SADI-S Procedure
A modern bariatric surgery combining sleeve gastrectomy with bowel bypass for significant, lasting weight loss in severe obesity.
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Body Composition
Sagittal Abdominal Diameter
Sagittal abdominal diameter measures the front-to-back depth of the abdomen, a strong indicator of hidden visceral fat.
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Screening
SARC-F (Sarcopenia Screening)
SARC-F is a five-question screen - strength, assistance walking, rising from a chair, climbing stairs and falls - that flags people who may have lost muscle.
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Conditions
Sarcopenia
Sarcopenia is the progressive loss of muscle mass and strength with age — losing weight without protecting muscle can worsen it.
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Conditions
Sarcopenic Obesity
Excess body fat coexisting with low muscle mass, requiring careful weight loss strategies to preserve strength.
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Procedures
SASI Bypass
A newer metabolic surgery combining sleeve gastrectomy with intestinal bypass for significant and sustained weight loss.
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Nutrition
Satiety
The feeling of fullness after eating that helps control appetite — influenced by protein, fibre, and food volume.
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Nutrition
Satiety Index
A scale ranking how filling different foods are for the same number of calories — high-satiety foods help you eat less without feeling hungry.
-
Screening
SCOFF Questionnaire
The SCOFF questionnaire is a five-question screening test for eating disorders: two or more yes answers means the person needs proper assessment before any weight-loss plan continues.
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Lifestyle
Screen Time and Weight
Screen time is linked to weight gain through less physical activity, more snacking, disrupted sleep and constant exposure to food advertising.
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Nutrition
Seaweed and Weight Management
Seaweed is a low-energy, fibre-rich food with a genuine place in a weight-management diet, but kombu can deliver dozens of times the daily iodine requirement in one bowl and hijiki carries inorganic arsenic.
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Lifestyle
Sedentary Behaviour
Prolonged sitting or reclining with low energy expenditure, which independently increases the risk of weight gain.
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Psychological
Self-Compassion and Weight Management
Self-compassion means treating yourself with the same kindness you would show a friend, rather than harsh self-criticism.
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Psychological
Self-Determination Theory and Weight Management
Self-determination theory explains why weight-loss goals a person genuinely chooses last longer than goals driven by pressure, guilt or external reward.
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Psychological
Self-Efficacy and Weight Loss
Self-efficacy is your belief in your own ability to carry out the behaviours needed to reach a goal — and it is one of the strongest predictors of lasting weight loss.
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Lifestyle
Self-Monitoring
Tracking your food, activity, and weight — consistently linked to greater weight loss and long-term success.
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Psychological
Sense of Coherence and Weight Management
Sense of coherence is how comprehensible, manageable and meaningful a person finds life - a personal resource that tracks with health behaviour and body weight.
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Hormones
Serotonin and Appetite
Serotonin is a signalling molecule that helps switch appetite off after a meal, and its activity links mood and eating so closely that many medicines that act on it also change weight.
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Foundations
Set Point Theory
The concept that your body defends a preferred weight range through hormonal and metabolic mechanisms.
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Hormones
Sex Hormone-Binding Globulin (SHBG)
Sex hormone-binding globulin (SHBG) is a liver protein that binds testosterone and oestrogen in the blood; it is lowered by high insulin and is a useful marker of insulin resistance.
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Medications
SGLT-2 Inhibitors and Weight
Diabetes medications that promote weight loss by causing the kidneys to excrete excess sugar through urine.
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Screening
Short Physical Performance Battery (SPPB)
The Short Physical Performance Battery is a ten-minute test of standing balance, walking speed and chair stands scored out of twelve that identifies mobility limitation, which matters because obesity lowers the score and a low score makes weight management harder.
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Medications
Sibutramine
A satiety-enhancing weight-loss drug withdrawn in 2010 due to increased heart and stroke risk.
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Screening
Six-Minute Walk Test
The six-minute walk test measures how far you can walk in six minutes on the flat - a simple, safe way to score fitness and daily function in obesity.
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Body Composition
Skinfold Thickness Measurement
Skinfold thickness measurement uses calipers to measure the layer of fat just beneath the skin at several body sites, giving an estimate of body fat percentage.
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Lifestyle
Sleep and Weight Loss
Sleep and weight are closely linked: short or poor sleep raises hunger hormones, lowers fullness signals and makes weight loss harder.
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Conditions
Sleep Apnoea
A sleep disorder where breathing repeatedly stops and starts, often linked to obesity.
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Lifestyle
Sleep Hygiene
The set of habits that promote quality sleep, which helps regulate hunger hormones and supports healthy weight.
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Lifestyle
Sleep Quality and Weight
Insufficient sleep disrupts hunger hormones and insulin sensitivity, making weight loss more difficult.
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Procedures
Sleeve Gastrectomy
A weight-loss surgery that removes about 80% of the stomach, reducing food intake and hunger hormone production.
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Lifestyle
Smoking Cessation and Weight Gain
The modest weight gain many people experience after quitting smoking, and how to manage it safely.
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Psychological
Social Comparison and Weight Management
Comparing your body and your progress with other people - especially the curated images on social media - reliably fuels body dissatisfaction and makes a sensible weight plan harder to sustain.
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Lifestyle
Social Support and Weight Loss
The role of family, friends, and group programmes in improving weight loss outcomes.
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Nutrition
Sodium and Weight Management
High salt intake does not itself cause fat gain, but it drives water retention, raises blood pressure and usually comes with processed food that is easy to overeat.
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Body Composition
Somatotype
Somatotype describes body build as three separate numbers - endomorphy for roundness and fat, mesomorphy for muscle and bone, ectomorphy for linearity - each rated from about 1 to 7.
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Hormones
Spexin
Spexin is a hormone made in fat tissue, the gut and the brain that reduces appetite - levels are typically lower in people with obesity and rise after weight loss.
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Psychological
Stages of Change (Transtheoretical Model)
The stages of change model describes five steps people move through to change a behaviour - precontemplation, contemplation, preparation, action and maintenance - and the support that helps is different at each stage.
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Lifestyle
Stair Climbing
Stair climbing is a free and easy way to add exercise to your day.
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Lifestyle
Step Count and Weight Loss
Counting steps is a popular and easy way to increase daily movement.
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Screening
STOP-BANG Questionnaire
The STOP-BANG questionnaire is a quick eight-point screening tool that estimates the risk of obstructive sleep apnoea, a condition that is common in people with obesity.
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Psychological
Stress Eating
Stress eating is eating in response to emotional or psychological stress rather than physical hunger.
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Lifestyle
Stress Management
Controlling stress responses that can trigger weight gain through emotional eating and hormonal changes.
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Hormones
Subclinical Hypothyroidism and Weight
Subclinical hypothyroidism is a mildly raised TSH with a normal free T4, and although it is common in people carrying excess weight, treating it with levothyroxine does not produce meaningful weight loss.
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Body Composition
Subcutaneous Fat
The soft fat layer just under your skin, generally less harmful than deep visceral fat around the organs.
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Nutrition
Sugar-Sweetened Beverages
Sugar-sweetened beverages are drinks with added sugar, such as soft drinks, sweetened teas, energy drinks and fruit cordials.
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Medications
Sulphonylureas and Weight Gain
Sulphonylureas, the long-established tablets for type 2 diabetes, typically add one to two and a half kilograms in the first year of treatment, which matters when weight is part of the treatment goal.
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Medications
Survodutide
A dual GLP-1/glucagon receptor agonist in development for obesity that aims to reduce appetite and boost energy expenditure.
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Procedures
Swallowable Gastric Balloon
A swallowable gastric balloon is swallowed as a capsule, filled with fluid in the stomach and left in place for about four months to reduce portions without surgery or endoscopy.
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Lifestyle
Swimming for Weight Loss
Swimming and water exercise burn energy with almost no load on the joints, and structured water-aerobic programmes have produced modest but real reductions in weight and waist.
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Medications
Tesofensine
An investigational weight loss tablet that affects three brain chemicals to suppress appetite and support metabolism.
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Hormones
Testosterone and Weight Loss
Testosterone supports muscle and metabolism — low levels are common in men with obesity, and weight loss itself raises testosterone.
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Foundations
Thermic Effect of Food (TEF)
The thermic effect of food, or TEF, is the energy your body burns just to digest, absorb and store the food you eat.
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Foundations
Thermogenesis
The body's process of producing heat through metabolic activity, influencing how many calories you burn.
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Medications
Thiazolidinediones and Weight Gain
Thiazolidinediones are tablets that make the body respond better to insulin but typically add two to five kilograms in the first year, mostly as fluid and subcutaneous fat rather than harmful visceral fat.
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Procedures
Thigh Lift (Thighplasty)
A thigh lift is body-contouring surgery that removes loose skin and fat from the thighs after major weight loss, giving the leg a tighter contour.
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Screening
Three-Factor Eating Questionnaire (TFEQ)
The Three-Factor Eating Questionnaire is a validated set of questions that scores three eating styles - cognitive restraint, uncontrolled eating and emotional eating - which shape how a person responds to a weight plan.
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Foundations
Thrifty Gene Hypothesis
The thrifty gene hypothesis suggests that genes which once helped our ancestors store fat efficiently during food shortages now make weight gain easier in today's food-rich environment.
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Conditions
Thyroid and Weight Gain
Thyroid hormones control your metabolic rate — an underactive thyroid slows it and commonly causes modest weight gain.
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Hormones
Thyroid Function
How well your thyroid gland produces metabolism-regulating hormones — an underactive thyroid can cause weight gain.
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Nutrition
Time-Restricted Eating
An eating pattern where all daily meals are consumed within an 8- to 10-hour window to support metabolic health.
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Complications
Tinnitus and Obesity
Tinnitus is the perception of ringing, buzzing or hissing with no external source, and people carrying excess weight report it more often - largely because the same vascular and metabolic problems that damage the inner ear are more common in obesity.
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Medications
Topiramate
A medication originally developed for epilepsy, used off-label and in combination formulations for weight loss.
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Body Composition
Total Body Water
Total body water is the fluid held in your cells and tissues — day-to-day scale swings are mostly water, not fat.
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Foundations
Total Daily Energy Expenditure (TDEE)
The total calories your body burns each day, used to set a personal calorie target for weight loss.
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Procedures
Transoral Outlet Reduction (TORe)
A non-surgical endoscopic procedure that tightens the stomach-intestine connection to restore weight loss after gastric bypass.
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Procedures
Transpyloric Shuttle
An endoscopic device that delays stomach emptying to promote fullness and support weight loss without surgery.
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Lifestyle
Travel and Weight Management
Holidays and long trips disrupt eating, sleep and activity routines, so a simple travel plan keeps weight and habits on track while you are away.
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Screening
Triglyceride-Glucose (TyG) Index
The triglyceride-glucose (TyG) index is a simple calculation from routine fasting blood tests that estimates insulin resistance.
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Conditions
Type 2 Diabetes
A metabolic disorder where the body cannot effectively use insulin, often linked to weight.
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Conditions
Type 2 Diabetes Remission
Type 2 diabetes remission means blood sugar levels return to the non-diabetic range and stay there for at least three months without glucose-lowering medication.
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Nutrition
Ultra-Processed Foods
Industrially manufactured foods linked to overeating and weight gain, and why reducing them is a cornerstone of weight management.
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Psychological
Urge Surfing
Urge surfing is a mindfulness technique for riding out a craving without acting on it, by observing the urge rise, peak and fall instead of fighting or feeding it.
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Screening
Uric Acid
Uric acid is a blood marker of purine metabolism that rises with excess weight and is linked to gout, kidney stones and metabolic risk.
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Complications
Urinary Incontinence and Obesity
Urinary incontinence — leaking urine by accident — is much more common with excess weight, and losing even 5–10% of your weight can substantially reduce leaks.
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Procedures
Vagal Nerve Blockade (vBloc)
An implantable device therapy that intermittently blocks hunger signals between the brain and stomach.
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Hormones
Vasopressin and Weight Regulation
Vasopressin is the body's water-conserving hormone, and a chronically high level tracks with abdominal fat, insulin resistance and a higher risk of type 2 diabetes.
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Hormones
Vaspin
Vaspin is an adipokine released mainly by visceral fat that appears to improve insulin sensitivity - levels are abnormal in obesity and shift with weight loss.
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Complications
Venous Thromboembolism and Obesity
Venous thromboembolism, or VTE, means blood clots that form in a vein, most often in the legs (deep vein thrombosis) or that travel to the lungs (pulmonary embolism).
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Procedures
Vertical Banded Gastroplasty (VBG)
An older restrictive stomach-stapling operation now largely replaced by sleeve gastrectomy and gastric bypass.
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Nutrition
Very Low-Calorie Diet (VLCD)
A very low-calorie diet, or VLCD, provides fewer than 800 calories a day, usually as meal-replacement shakes, and can produce rapid early weight loss.
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Nutrition
Vinegar and Glycaemic Response
How the acetic acid in vinegar helps lower post-meal blood sugar spikes, supporting glycaemic control and appetite regulation.
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Body Composition
Visceral Adiposity Index (VAI)
The visceral adiposity index combines waist circumference, BMI, triglycerides and HDL cholesterol into a single score estimating how much fat is stored around the abdominal organs.
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Body Composition
Visceral Fat
Fat stored around internal organs — the most dangerous type of body fat.
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Hormones
Visfatin (NAMPT)
Visfatin, also called NAMPT, is a protein made by fat tissue and other cells that was once thought to act like insulin; levels are often higher in obesity and insulin resistance, but it remains a research marker rather than a clinical test.
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Nutrition
Vitamin D and Weight Management
A nutrient often low in people with obesity, important to check and correct during a weight loss journey.
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Nutrition
Volumetrics Diet
A dietary approach focused on low-calorie-density foods that allow larger, more satisfying portions for fewer calories.
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Screening
Waist Circumference
Waist circumference is a simple tape measurement that estimates how much fat is stored around your organs — a key marker of health risk, even when BMI looks normal.
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Body Composition
Waist Circumference Measurement
Waist circumference is a simple tape-measure check around your belly that shows how much fat you carry around your organs.
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Screening
Waist-Hip Ratio
A measure of fat distribution — central obesity indicates higher health risk.
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Screening
Waist-to-Height Ratio
The waist-to-height ratio compares your waist circumference with your height, and a value above 0.5 signals excess belly fat and higher health risk.
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Lifestyle
Walking for Weight Loss
Walking is the most sustainable form of exercise — free, low-impact and easy to fit into daily life in Singapore.
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Screening
Water Weight
Temporary fluid retention that can mask true fat loss on the scale.
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Medications
Weekly GLP-1 Injection
A once-weekly GLP-1 receptor agonist injection used in type 2 diabetes that also supports meaningful weight loss. Prescription only, after medical assessment.
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Body Composition
Weight Cycling
Yo-yo dieting — the repeated pattern of losing and regaining weight, which can slow metabolism.
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Foundations
Weight Loss Plateaus
A normal phase during weight loss where progress stalls due to metabolic adaptation and reduced energy needs.
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Foundations
Weight Maintenance
The long-term phase of weight management focused on sustaining weight loss through continued healthy habits and medical support.
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Foundations
Weight Regain
Putting weight back on after losing it — driven by hormonal and metabolic defences that make maintenance hard; why ongoing support matters.
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Foundations
Weight Stigma
Negative attitudes and discrimination based on body weight — a barrier to seeking healthcare that independently worsens health outcomes.
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Lifestyle
Weight-Loss Plateau
A weight-loss plateau is a period — often several weeks — when weight stops falling despite doing the same things. It is a normal, expected phase.
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Body Composition
White Adipose Tissue
White adipose tissue is the body's main fat store - an active organ that releases hormones and influences appetite, insulin resistance and inflammation.
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Nutrition
Whole Grains and Weight Management
Whole grains keep the bran and germ, digest slowly and increase fullness, and swapping refined grains for them is linked to less weight gain over time.
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Psychological
Willpower and Weight Loss
Willpower is the mental effort used to resist an immediate temptation, and research shows it is a limited, fluctuating resource - which is why relying on it alone rarely keeps weight off.
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Complications
Wound Healing and Obesity
Excess weight slows wound healing - fat tissue has a poorer blood supply, inflammation stays switched on and infection is more likely, so wounds close more slowly.
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Lifestyle
Yo-Yo Dieting
Yo-yo dieting — also called weight cycling — is the repeated loss and regain of weight through cycles of strict dieting and relapse.
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Lifestyle
Yoga and Weight Management
Yoga combines physical postures, breathing and mindfulness, and it can support weight management in several ways.
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