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Hormones
Peptide YY (PYY)
A gut hormone released after eating that signals fullness to the brain and reduces appetite.
PLAIN ENGLISH
Patient-Friendly Explanation
Peptide YY, or PYY, is a hormone released by your gut after you eat that tells your brain you are full. Higher levels of PYY help you feel satisfied sooner and stop eating. Certain foods and weight loss treatments can influence how much PYY your body releases.
MEDICAL
Clinical Definition
Peptide YY (PYY) is an anorexigenic gut hormone secreted by L-cells of the distal ileum and colon in proportion to caloric intake. It acts on Y2 receptors in the hypothalamus and vagal afferents to reduce appetite and delay gastric emptying. PYY levels rise after a meal and are reduced in obesity, contributing to impaired satiety signalling.
KEY INSIGHT
Why It Matters
Understanding PYY helps explain why some people struggle to feel full and how GLP-1-based medications and certain eating patterns can restore satiety. Accord Medical Clinic’s weight management programme targets these hormonal pathways to help you achieve lasting results.
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This article is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional for medical concerns. Accord Medical Clinic Singapore is an MOH-registered medical clinic in Singapore. Dr Joseph Wang (Family Physician) provides medical weight management consultations.