Bupropion
Bupropion is a medication that affects brain chemicals linked to appetite and cravings, and may support weight loss as part of a comprehensive programme.
Plain English
Patient-Friendly Explanation
Bupropion is a medication originally developed as an antidepressant that can also help some people lose weight. It affects brain chemicals involved in appetite and food cravings, making it easier to follow a healthy eating plan.
Medical
Clinical Definition
Bupropion is a norepinephrine-dopamine reuptake inhibitor (NDRI) that increases synaptic concentrations of norepinephrine and dopamine. Its weight-loss effects are thought to stem from POMC neuron activation in the hypothalamus, which suppresses appetite. When combined with naltrexone, the synergistic effect produces more significant and sustained weight reduction than either agent alone.
Key Insight
Why It Matters
Understanding Bupropion's role in weight management helps patients make informed decisions about medication options. At Accord Medical Clinic, Dr Joseph Wang can assess whether Bupropion-based treatments are appropriate for your weight loss journey and overall health.
Sources
Reviewed against standard medical references.
Medically reviewed by
Family Physician & Registered Acupuncturist, Accord Medical Clinic. MBBS (NUS), Graduate Diploma in Family Medicine (NUS), Graduate Diploma in Acupuncture (Singapore College of TCM).
Last reviewed: August 2026
This page is general health education, not medical advice. Whether any treatment is appropriate for you is a decision made in consultation after assessment.
