Hyperinsulinaemia
A condition of chronically elevated blood insulin levels that promotes fat storage and complicates weight loss.
Plain English
Patient-Friendly Explanation
Hyperinsulinaemia means having too much insulin in your blood. When your body's cells become resistant to insulin, your pancreas compensates by producing more and more of it. High insulin levels promote fat storage and make it harder to lose weight, creating a challenging cycle that requires targeted dietary and medical strategies to break.
Medical
Clinical Definition
Hyperinsulinaemia is characterised by fasting insulin levels exceeding the normal reference range, typically above 25 μIU/mL, often preceding overt hyperglycaemia by years. It arises from pancreatic β-cell compensation for peripheral insulin resistance and is independently associated with increased cardiovascular risk, enhanced hepatic lipogenesis, and impaired lipolysis. Chronic hyperinsulinaemia drives weight gain by promoting anabolic pathways and suppressing fat oxidation, establishing a feed-forward loop of worsening insulin resistance.
Key Insight
Why It Matters
Addressing hyperinsulinaemia is often the key to sustainable weight loss in patients with prediabetes or metabolic syndrome. Dr. Joseph Wang and the Accord Medical team use advanced metabolic testing to identify and treat hyperinsulinaemia as part of a comprehensive weight management programme.
Sources
Reviewed against standard medical references.
Medically reviewed by
Family Physician & Registered Acupuncturist, Accord Medical Clinic. MBBS (NUS), Graduate Diploma in Family Medicine (NUS), Graduate Diploma in Acupuncture (Singapore College of TCM).
Last reviewed: August 2026
This page is general health education, not medical advice. Whether any treatment is appropriate for you is a decision made in consultation after assessment.
