Accord Medical Clinic – Singapore

Welcome to Accord Medical Clinic Address Blk 325 Ubi Avenue 1 #01-701 Singapore

6844 1528

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Weight Management Library

Evidence-based medical weight management terms explained by Dr Joseph Wang

Conditions

Acanthosis Nigricans

Acanthosis nigricans is a skin condition causing dark, velvety patches — a visible sign of insulin resistance linked to excess weight.

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Lifestyle

Active Commuting and Weight

Using walking, cycling, or public transport for daily travel to naturally build physical activity into routines and support healthy weight management.

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Foundations

Adaptive Thermogenesis

The body's metabolic defence mechanism that disproportionately slows energy expenditure during and after weight loss.

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Nutrition

Added Sugars

Added sugars are sugars and syrups added to foods during processing, which contribute empty calories and are linked to obesity, diabetes, and fatty liver disease.

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Foundations

Adipogenesis

The biological process by which the body creates new fat cells from precursor cells, influencing energy storage and metabolism.

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Foundations

Adipokines

Bioactive signalling proteins secreted by fat cells that regulate metabolism, inflammation, and appetite throughout the body.

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Foundations

Adipose Tissue

Adipose tissue is the body's specialised fat storage tissue that plays a critical role in energy balance, hormone production, and metabolic health.

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Procedures

Adjustable Gastric Band

A reversible bariatric procedure using an adjustable silicone band around the stomach to restrict food intake.

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Lifestyle

Alcohol and Weight Management

Alcohol adds calories, lowers restraint and stalls fat burning, so cutting back supports weight loss.

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Foundations

Anorexigenic Signals

Anorexigenic signals are the body's natural "stop eating" messages — chemical messengers that promote fullness and suppress appetite after eating.

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Nutrition

Anti-Inflammatory Diet

A diet rich in fruits, vegetables, and omega-3s that reduces chronic inflammation and supports healthy weight loss.

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Foundations

Appetite Regulation

The neuroendocrine system of hormones and brain signals that controls hunger and fullness, targeted by modern weight loss medications.

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Nutrition

Artificial Sweeteners

Artificial sweeteners provide sweetness without calories, and may help reduce sugar intake — but their long-term effects on weight and metabolism are complex.

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Procedures

Aspiration Therapy

A minimally invasive procedure that removes a portion of stomach contents after meals to reduce calorie absorption.

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Conditions

Bardet-Biedl Syndrome

A rare genetic ciliopathy characterised by severe early-onset obesity caused by impaired hypothalamic appetite regulation, requiring specialised multidisciplinary care.

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Procedures

Bariatric Prehabilitation

A structured pre-surgery programme of diet, exercise, and lifestyle changes that prepares patients physically and mentally for bariatric procedures.

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Procedures

Bariatric Surgery

Surgical procedures that alter the digestive system to promote weight loss.

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Body Composition

Basal Metabolic Rate

Calories your body burns at complete rest — the foundation of energy expenditure.

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Lifestyle

Behavioural Therapy for Weight Loss

A psychological approach to weight management that helps change eating habits, identify triggers, and build sustainable healthy behaviours.

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Procedures

Biliopancreatic Diversion

Biliopancreatic diversion (BPD) is a major malabsorptive bariatric surgery that reduces nutrient absorption by rerouting the small intestine, producing substantial and sustained weight loss.

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Psychological

Binge Eating Disorder

A serious eating disorder involving recurrent episodes of uncontrolled overeating.

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Procedures

Bioelectrical Impedance Analysis (BIA)

A quick, non-invasive test that uses a small electrical signal to estimate your body fat percentage, muscle mass, and hydration levels.

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Lifestyle

Blue Light and Weight

Evening blue light from screens disrupts sleep hormones and metabolism, contributing to weight gain — reducing exposure supports weight management.

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Body Composition

BMI

Body Mass Index — a screening tool using height and weight to assess weight status.

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Screening

Body Composition Analysis

Measurement of body fat percentage, muscle mass, and distribution.

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Psychological

Body Dysmorphia

Body dysmorphia is a mental health condition involving obsessive focus on perceived appearance flaws, which can complicate weight-loss efforts.

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Body Composition

Body Fat Percentage

Body fat percentage measures the proportion of body weight from fat, providing a more accurate health picture than BMI alone.

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Foundations

Body Roundness Index (BRI)

A body shape index that uses waist circumference and height to estimate abdominal fat distribution, providing more accurate health risk assessment than BMI alone.

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Foundations

Brown Adipose Tissue

Brown adipose tissue (BAT) is a special type of fat that burns calories to produce heat, playing a unique role in energy expenditure and metabolic…

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Medications

Bupropion

Bupropion is a medication that affects brain chemicals linked to appetite and cravings, and may support weight loss when used as part of a comprehensive…

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Lifestyle

Caffeine and Weight Management

A mild stimulant that briefly boosts metabolism and curbs appetite but has limited effect on long-term weight loss.

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Medications

Cagrilintide

A long-acting amylin analogue given as a weekly injection to enhance feelings of fullness and reduce food intake.

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Medications

CagriSema

CagriSema is an investigational combination injection of cagrilintide and semaglutide that targets multiple appetite pathways for enhanced weight loss.

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Nutrition

Caloric Deficit

Consuming fewer calories than your body burns, the foundation of weight loss.

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Nutrition

Capsaicin and Weight Management

The active compound in chilli peppers that may boost calorie burning and reduce appetite as a natural adjunct to weight management.

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Complications

Cardiovascular Disease

Heart and blood vessel disease — the leading cause of obesity-related death.

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Medications

Cetilistat

Cetilistat is a weight-loss medication that blocks fat absorption in the digestive system, designed to support weight management with fewer side effects.

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Lifestyle

Chewing Rate and Satiety

Eating slowly and chewing thoroughly gives your body time to register fullness, helping you consume fewer calories without feeling deprived.

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Conditions

Chronic Kidney Disease and Obesity

Chronic Kidney Disease (CKD) is gradual loss of kidney function, and obesity is a major risk factor — weight loss can help slow its progression.

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Nutrition

Chrononutrition

The science of how meal timing interacts with your body clock to influence metabolism and weight.

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Lifestyle

Circadian Rhythm and Weight

The relationship between your body's internal clock and weight regulation, showing how meal timing and sleep patterns affect metabolism and fat storage.

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Lifestyle

Cold-Induced Thermogenesis

Cold-induced thermogenesis activates brown fat to burn calories for heat, offering a modest metabolic boost that can complement weight management efforts.

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Medications

Contrave

A prescription combination medication (naltrexone/bupropion) that reduces hunger and food cravings for weight management.

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Hormones

Cortisol

Cortisol is the body's primary stress hormone, and chronically elevated levels can promote belly fat storage and increased appetite.

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Procedures

Cryolipolysis

A non-surgical fat freezing treatment that destroys fat cells in small, targeted areas of the body.

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Lifestyle

Culinary Medicine

An evidence-based approach that combines nutrition science with practical cooking skills to help patients make healthier food choices for long-term weight management.

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Conditions

Cushing's Syndrome

A hormonal disorder caused by prolonged exposure to high cortisol levels, leading to rapid central weight gain.

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Nutrition

DASH Diet

The DASH Diet focuses on fruits, vegetables, whole grains, and low-fat dairy to reduce blood pressure and support healthy weight management.

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Foundations

De Novo Lipogenesis

The metabolic process where your liver converts excess carbohydrates into stored fat.

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Conditions

Depression and Obesity

Depression and obesity have a bidirectional relationship — each increases the risk and severity of the other, requiring integrated treatment.

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Foundations

DEXA Scan

A DEXA scan is a low-radiation imaging test that precisely measures bone density, body fat percentage, and lean muscle mass to guide weight management.

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Conditions

Diabesity

The close link between obesity and type 2 diabetes, where losing weight is key to controlling blood sugar.

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Nutrition

Dietary Fibre

Dietary fibre is the indigestible part of plant foods that promotes fullness, supports gut health, and aids weight management.

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Nutrition

Dietary Protein

A key nutrient that preserves muscle, promotes fullness, and supports healthy weight loss.

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Medications

Diethylpropion

A short-term prescription appetite suppressant that helps jump-start weight loss by reducing hunger signals in the brain.

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Lifestyle

Digital Health Tools for Weight Loss

Digital health tools like apps, wearables, and telehealth can support weight loss through self-monitoring and accountability, especially when combined with professional medical guidance.

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Medications

Dulaglutide (Trulicity)

Dulaglutide (Trulicity) is a once-weekly GLP-1 injection for type 2 diabetes that also supports meaningful weight loss.

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Procedures

Duodenal Mucosal Resurfacing (DMR)

A minimally invasive endoscopic procedure that renews the duodenal lining to improve the bodys hormonal response to food and help control blood sugar.

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Procedures

Duodenal Switch

A combined restrictive and malabsorptive bariatric procedure that produces the greatest weight loss among all surgical options for severe obesity.

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Procedures

Duodenal-Jejunal Bypass Liner (EndoBarrier)

A removable intestinal sleeve placed by endoscopy that mimics gastric bypass hormone changes to reduce appetite and improve blood sugar.

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Conditions

Dyslipidaemia

Dyslipidaemia is an imbalance of blood fats — high bad cholesterol or triglycerides — that increases heart disease risk and often improves with weight loss.

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Nutrition

Eating Frequency

Eating frequency — how many meals you eat per day — matters less for weight than total caloric intake and food quality, though irregular patterns…

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Lifestyle

Eating Rate

The speed at which you eat meals — faster eating is linked to higher calorie intake and weight gain because the brain needs about 20…

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Psychological

Emotional Eating

Using food to cope with emotions rather than physical hunger.

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Procedures

Endoscopic Gastric Remodelling

A non-surgical, incisionless procedure that reshapes the stomach through an endoscope to reduce its capacity and support weight loss.

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Procedures

Endoscopic Sleeve Gastroplasty

A non-surgical, incisionless weight-loss procedure that reduces stomach size using an endoscope and internal sutures.

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Foundations

Energy Balance

The fundamental principle of weight management describing the relationship between calories consumed and calories burned through daily functions and physical activity.

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Foundations

Energy Density

Energy density is the number of calories per gram of food — choosing lower-density foods helps you feel full while controlling calorie intake.

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Foundations

Energy Flux

Energy flux is the rate of energy turnover in your body — high flux supports better weight control and metabolic health.

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Lifestyle

Environmental Design for Weight Loss

The practice of arranging your surroundings to make healthy eating and activity choices the easiest and most natural option.

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Medications

Exenatide (Byetta)

The first FDA-approved GLP-1 receptor agonist, originally derived from Gila monster saliva — a twice-daily injection that improves blood sugar and supports weight loss.

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Lifestyle

Exercise Physiology

How physical activity affects body weight, metabolism, and health.

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Lifestyle

Exercise Snacking

Exercise snacking involves short, 1–2 minute bursts of vigorous activity spread throughout the day to improve fitness and metabolism.

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Foundations

Fat-Free Mass

Fat-Free Mass is everything in your body that is not fat — muscles, bones, organs, and water. Preserving it during weight loss is essential to…

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Conditions

Fatty Liver Disease

Accumulation of fat in liver cells, strongly associated with obesity.

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Foundations

Foetal Programming of Obesity

Foetal programming describes how maternal health during pregnancy can influence a child's lifelong obesity risk through epigenetic changes.

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Conditions

Food Addiction and Obesity

Food addiction is a pattern of compulsive overeating driven by the same brain reward pathways involved in substance addiction, and it is increasingly recognised as…

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Lifestyle

Food Cravings

Intense, selective urges to eat specific foods, driven by brain chemistry rather than true hunger.

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Nutrition

Food Labels and Weight Management

The skill of reading nutrition labels to make informed food choices that support weight loss goals.

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Lifestyle

Food Reward

Food reward is the brain pleasure and motivation response to eating, especially processed foods that can override fullness signals and drive overeating.

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Conditions

Gallstones

Gallstones are hardened deposits of digestive fluid that form in the gallbladder — obesity and rapid weight loss both increase the risk of developing them.

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Procedures

Gastric Balloon

A non-surgical weight loss procedure placing a soft balloon in the stomach.

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Procedures

Gastric Botox

An endoscopic procedure using botulinum toxin injections into the stomach to slow gastric emptying and reduce appetite.

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Procedures

Gastric Bypass

Gastric bypass is a surgical weight-loss procedure that reduces stomach size and reroutes the intestine, leading to significant and lasting weight loss.

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Procedures

Gastric Electrical Stimulation

An implanted pacemaker-like device that sends pulses to the stomach to promote fullness and delay emptying.

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Procedures

Gastric Plication

A reversible weight loss surgery that folds and stitches the stomach to reduce its size without removing tissue.

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Complications

GERD

GERD is a chronic acid reflux condition that is common with excess weight and often improves significantly with weight loss.

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Hormones

Ghrelin

The hunger hormone — stimulates appetite before meals.

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Medications

GLP-1 Receptor Agonists

A class of medications that mimic the GLP-1 hormone to regulate appetite and blood sugar.

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Nutrition

Glycaemic Index

A measure of how quickly foods raise blood sugar levels.

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Nutrition

Glycaemic Load

Glycaemic load measures how much a typical serving of food actually raises blood sugar — a more practical tool than glycaemic index alone.

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Conditions

Gout

Gout is a painful arthritic condition linked to high uric acid, and weight loss can significantly reduce the frequency of attacks.

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Foundations

Gut Microbiome

The trillions of bacteria in your digestive system that influence metabolism, appetite, and weight regulation.

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Foundations

Gut-Brain Axis

The two-way communication network between your gut and brain that regulates hunger, fullness, and metabolism.

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Lifestyle

Habit Stacking

A behavioural technique that pairs a new healthy habit with an existing routine to make lifestyle changes easier and more sustainable.

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Screening

HbA1c (Glycated Haemoglobin)

A blood test that measures your average blood sugar over two to three months, a key marker of metabolic health during weight loss.

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Screening

Health Screening

Comprehensive medical check-up to assess weight-related health risks.

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Lifestyle

High-Intensity Interval Training (HIIT)

HIIT alternates short bursts of intense exercise with rest — a time-efficient way to burn fat and boost metabolism for hours afterwards.

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Lifestyle

Hydration and Weight Management

How adequate water intake supports weight loss by boosting metabolism, reducing calorie intake, and replacing high-calorie beverages.

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Conditions

Hyperinsulinaemia

A condition of chronically elevated blood insulin levels that promotes fat storage and complicates weight loss.

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Conditions

Hyperphagia

A medical condition characterised by abnormally intense and persistent hunger that contributes to weight gain and requires clinical evaluation.

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Conditions

Hypertension

High blood pressure — a common condition often linked to excess weight.

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Conditions

Hyperuricaemia and Obesity

Hyperuricaemia — elevated blood uric acid — is strongly linked to obesity and can lead to gout; weight loss helps lower uric acid levels naturally.

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Conditions

Hypothalamic Obesity

Hypothalamic obesity is weight gain caused by damage to the hypothalamus, the brain centre for hunger control, leading to relentless appetite and metabolic disruption.

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Conditions

Hypothyroidism

An underactive thyroid gland that slows metabolism and can contribute to weight gain and difficulty losing weight.

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Complications

Idiopathic Intracranial Hypertension (IIH)

Raised pressure inside the skull linked to obesity, causing headaches and vision problems that often improve with weight loss.

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Medications

Incretin-Based Therapies

Incretin-based therapies are a class of medications that mimic gut hormones to lower blood sugar, suppress appetite, and promote significant weight loss.

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Conditions

Infertility and Obesity

Obesity can disrupt hormonal balance and ovulation in both men and women, making it harder to conceive — but weight loss can significantly improve fertility…

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Hormones

Insulin Resistance

A condition where cells do not respond well to insulin, driving weight gain.

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Nutrition

Intermittent Fasting

An eating pattern cycling between periods of eating and fasting.

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Psychological

Intuitive Eating

Eating guided by your body's natural hunger and fullness signals rather than strict diet rules.

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Procedures

Jejunoileal Bypass

Jejunoileal bypass was a historical malabsorptive weight-loss surgery abandoned due to severe complications — a milestone in bariatric surgery evolution.

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Nutrition

Ketogenic Diet

A very low-carbohydrate, high-fat diet that induces ketosis, causing the body to burn fat for fuel and often producing rapid initial weight loss.

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Hormones

Leptin

The satiety hormone — regulates hunger and energy balance.

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Screening

Lipid Profile

A lipid profile is a blood test measuring cholesterol and triglycerides — a key screening tool to assess heart disease risk during weight management.

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Conditions

Lipidema

Lipidema is a chronic condition causing painful, abnormal fat accumulation mainly in the legs and arms, often mistaken for simple obesity.

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Conditions

Lipodystrophy

A group of rare disorders causing abnormal fat distribution and severe metabolic complications from impaired fat storage.

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Conditions

Lipohypertrophy

Lipohypertrophy is abnormal fat accumulation at insulin injection sites that can interfere with diabetes management and complicate weight loss efforts.

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Foundations

Lipolysis

The biological process of breaking down stored fat into usable energy, driven by a caloric deficit and regulated by hormones like insulin and adrenaline.

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Procedures

Liposuction

Liposuction is a cosmetic fat-removal procedure for body contouring — not a weight-loss treatment or obesity solution.

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Conditions

Lipotoxicity

The damaging effects of excess fat accumulation in organs like the liver, pancreas, and muscles — a key mechanism linking obesity to diabetes and organ…

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Medications

Liraglutide (Saxenda)

A daily injectable GLP-1 receptor agonist that reduces appetite and promotes weight loss in adults with obesity.

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Medications

Lorcaserin

A selective serotonin receptor agonist that reduces appetite by activating satiety pathways in the brain, withdrawn in 2020 after long-term safety review.

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Nutrition

Low-Glycaemic Diet

A low-glycaemic diet focuses on foods that cause a slow, steady rise in blood sugar, helping with appetite control, sustained energy, and more effective weight…

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Nutrition

Macronutrients

The three main nutrients: carbohydrates, proteins, and fats — all essential for health.

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Medications

Mazindol

Mazindol is an appetite suppressant that works on the brain hunger control centre, historically used for short-term weight management in resistant cases.

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Lifestyle

Meal Prepping

A structured food preparation strategy that makes healthy eating convenient by preparing meals in advance.

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Nutrition

Mediterranean Diet

A balanced, evidence-based eating pattern rich in vegetables, olive oil, fish, and whole grains — recommended for sustainable weight management and metabolic health.

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Nutrition

Medium-Chain Triglycerides

Medium-chain triglycerides are fats that bypass normal digestion, providing quick energy and modestly boosting metabolism and satiety for weight management support.

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Conditions

Menopause and Weight Gain

Weight gain driven by declining oestrogen during menopause — shifts fat storage to the abdomen, slows metabolism, and increases cardiometabolic risk.

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Body Composition

Metabolic Adaptation

The body's natural slowing of metabolism in response to weight loss.

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Foundations

Metabolic Flexibility

Metabolic flexibility is the body's ability to switch between burning carbohydrates and fats — poor flexibility is linked to weight gain and insulin resistance.

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Foundations

Metabolic Health

How well your body regulates blood sugar, cholesterol, and blood pressure, a fuller measure of health than weight alone.

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Conditions

Metabolic Syndrome

A cluster of conditions that increase risk of heart disease, stroke, and diabetes.

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Medications

Metformin

Metformin is a diabetes medication that can support modest weight loss by improving insulin sensitivity and reducing liver sugar production.

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Psychological

Mindful Eating

Mindful eating is the practice of paying full attention to eating experiences to recognise hunger cues and break emotional eating patterns.

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Procedures

Mini Gastric Bypass (OAGB)

The Mini Gastric Bypass (OAGB) is a simplified weight loss surgery using a single connection to reduce stomach size and calorie absorption, with strong long-term…

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Lifestyle

Morning vs Evening Exercise

Morning exercise may enhance fat burning and consistency, while evening exercise may boost strength and performance — the best time is the one you can…

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Lifestyle

Movement Breaks

Short bursts of light activity taken throughout the day to break up long periods of sitting — improves blood sugar control and boosts daily calorie…

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Medications

Naltrexone

Naltrexone is an opioid blocker that, combined with bupropion, helps reduce food cravings and support medically supervised weight loss.

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Lifestyle

NEAT (Non-Exercise Activity Thermogenesis)

The calories burned through everyday non-exercise activities like walking, standing, and household chores.

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Conditions

Night Eating Syndrome

Night Eating Syndrome is a condition where a person consumes a large portion of daily calories after dinner or during the night, often with morning…

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Conditions

Non-Alcoholic Steatohepatitis (NASH)

NASH is the inflammatory, progressive form of fatty liver disease that can lead to cirrhosis — weight loss of 7–10% is the most effective treatment.

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Conditions

Obesity

A chronic medical condition defined by excessive body fat that increases health risks.

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Foundations

Obesity Classification (Class I, II, III)

A BMI-based grading of obesity severity that guides which weight-loss treatments are appropriate.

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Conditions

Obesity Hypoventilation Syndrome

A serious breathing disorder in people with severe obesity where excess weight restricts lung function.

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Foundations

Obesity Paradox

The observation that overweight or mildly obese patients with certain chronic diseases may have better survival — highlighting the complexity of weight-health relationships.

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Conditions

Obesity-Related Glomerulopathy

Obesity-Related Glomerulopathy is kidney damage caused by excess weight, leading to protein leakage and progressive decline in kidney function.

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Foundations

Obesogenic Environment

An obesogenic environment is a setting that promotes weight gain through easy access to unhealthy food and barriers to physical activity.

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Nutrition

Omega-3 Fatty Acids and Weight

Omega-3 fatty acids are healthy fats found in fish and certain plant oils that reduce inflammation, support metabolism, and may enhance the body composition benefits…

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Foundations

Orexigenic Signals

Orexigenic signals are the body's natural "eat more" messages — hormones and brain chemicals that drive hunger and food intake.

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Medications

Orforglipron

An oral GLP-1 receptor agonist in development that mimics natural hunger-regulating hormones without injections.

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Complications

Osteoarthritis

Joint degeneration worsened by excess weight, particularly in knees and hips.

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Medications

Oxyntomodulin

A gut hormone that reduces appetite and is being developed as a new injectable treatment for obesity.

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Medications

Panbesy

A prescription appetite suppressant used for short-term weight management under medical supervision.

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Conditions

PCOS

Polycystic Ovary Syndrome — a hormonal disorder common in women, linked to weight.

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Hormones

Peptide YY (PYY)

A gut hormone released after eating that signals fullness to the brain and reduces appetite.

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Medications

Phendimetrazine

A short-term prescription appetite suppressant used as part of a medically supervised weight loss programme.

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Medications

Phentermine

Phentermine is a short-term prescription appetite suppressant used alongside diet and exercise for medically supervised weight loss.

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Nutrition

Plant-Based Diets for Weight Management

Eating patterns centred on plant foods that support weight loss through lower calorie density and higher satiety.

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Lifestyle

Portion Control

Portion control is the practice of managing the amount of food you eat at each meal, a proven behavioural strategy for reducing calorie intake without…

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Conditions

Post-Bariatric Hypoglycaemia

A complication of weight loss surgery where blood sugar drops too low after eating, caused by an exaggerated insulin response to rapid food transit.

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Conditions

Prader-Willi Syndrome

A rare genetic disorder causing constant extreme hunger, slow metabolism, and lifelong weight management challenges.

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Medications

Pramlintide

A synthetic amylin analogue injection that slows gastric emptying and promotes satiety — used as an adjunct therapy for diabetes and weight management.

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Nutrition

Prebiotics and Weight Management

Non-digestible fibres that feed beneficial gut bacteria — may support weight management by improving metabolism and appetite regulation through the gut-brain axis.

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Conditions

Prediabetes

Prediabetes is a condition where blood sugar levels are higher than normal but not yet diabetic — a critical window where weight loss can reverse…

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Procedures

Prescription Digital Therapeutics

FDA-approved app-based therapy programmes prescribed by doctors to support weight loss through behavioural change.

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Procedures

Primary Obesity Surgery Endolumenal (POSE)

POSE is a non-surgical, incisionless endoscopic procedure that reduces stomach capacity to promote weight loss by helping you feel full sooner.

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Nutrition

Probiotics and Weight Management

Probiotics are beneficial live bacteria that support gut health and may aid weight management by improving digestion, reducing inflammation, and influencing appetite hormones.

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Nutrition

Protein Leverage Hypothesis

The protein leverage hypothesis suggests the body overeats calories from fats and carbs to meet a fixed daily protein target, which may contribute to weight…

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Nutrition

Protein Timing

The strategic distribution of protein intake across meals to preserve muscle mass, enhance satiety, and support metabolism during weight loss.

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Lifestyle

Resistance Training

Resistance training builds muscle through exercises like weight lifting, boosting metabolism and supporting sustainable weight loss.

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Nutrition

Resistant Starch

Resistant starch is a carbohydrate that resists digestion, feeding beneficial gut bacteria to improve blood sugar control, appetite regulation, and metabolic health.

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Foundations

Respiratory Quotient

Respiratory Quotient reveals whether your body is burning carbohydrates or fats for energy, helping tailor your weight management plan.

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Foundations

Resting Metabolic Rate (RMR)

Resting Metabolic Rate is the energy your body uses at complete rest — understanding it helps create personalised weight management plans.

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Medications

Retatrutide

Retatrutide is an investigational triple-hormone agonist that achieved up to 24% body weight loss in clinical trials, approaching surgical-level results.

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Procedures

Revisional Bariatric Surgery

A second weight loss operation to address inadequate weight loss or weight regain after initial bariatric surgery.

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Medications

Rimonabant

Rimonabant was the first CB1 receptor antagonist for weight loss — withdrawn due to psychiatric side effects but historically significant.

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Procedures

Robotic Bariatric Surgery

Robotic bariatric surgery uses a surgeon-controlled robotic platform to perform weight-loss procedures with enhanced precision, 3D vision, and smaller incisions.

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Procedures

SADI-S Procedure

A modern bariatric surgery combining sleeve gastrectomy with bowel bypass for significant, lasting weight loss in severe obesity.

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Conditions

Sarcopenic Obesity

A condition where excess body fat coexists with low muscle mass, requiring careful weight loss strategies to preserve strength and metabolic health.

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Procedures

SASI Bypass

SASI (Single Anastomosis Sleeve Ileal) Bypass is a newer metabolic surgery combining sleeve gastrectomy with intestinal bypass for significant and sustained weight loss.

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Nutrition

Satiety

Satiety is the feeling of fullness after eating that helps control appetite — influenced by protein, fibre, and food volume.

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Lifestyle

Sedentary Behaviour

Sedentary behaviour refers to prolonged sitting or reclining with low energy expenditure, which independently increases the risk of weight gain and metabolic disease.

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Lifestyle

Self-Monitoring

Self-monitoring means tracking your food, activity, and weight — consistently linked to greater weight loss and long-term success.

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Medications

Semaglutide

A GLP-1 receptor agonist medication used for weight management and type 2 diabetes.

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Foundations

Set Point Theory

The concept that your body defends a preferred weight range through hormonal and metabolic mechanisms, explaining why sustained weight loss requires long-term strategies.

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Medications

Setmelanotide (Imcivree)

An injectable medication that treats severe obesity caused by specific rare genetic conditions by restoring the brain's fullness signal.

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Medications

SGLT-2 Inhibitors and Weight

Diabetes medications that promote weight loss by causing the kidneys to excrete excess sugar through urine, resulting in a net calorie loss of 200-300 kcal…

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Medications

Sibutramine

A satiety-enhancing weight-loss drug withdrawn in 2010 due to increased heart and stroke risk.

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Conditions

Sleep Apnoea

A sleep disorder where breathing repeatedly stops and starts, often linked to obesity.

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Lifestyle

Sleep Hygiene

Sleep hygiene is the set of habits that promote quality sleep, which helps regulate hunger hormones and supports healthy weight.

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Lifestyle

Sleep Quality and Weight

Insufficient sleep disrupts hunger hormones and insulin sensitivity, making weight loss more difficult.

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Procedures

Sleeve Gastrectomy

Sleeve gastrectomy is a weight-loss surgery that removes about 80% of the stomach, reducing food intake and hunger hormone production.

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Lifestyle

Smoking Cessation and Weight Gain

The modest weight gain many people experience after quitting smoking, and how to manage it safely.

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Lifestyle

Social Support and Weight Loss

The role of family, friends, and group programmes in improving weight loss outcomes through accountability and encouragement.

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Lifestyle

Stress Management

Stress management is the practice of controlling stress responses that can trigger weight gain through emotional eating and hormonal changes.

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Body Composition

Subcutaneous Fat

The soft fat layer just under your skin, generally less harmful than deep visceral fat around the organs.

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Medications

Survodutide

Survodutide is a dual GLP-1/glucagon receptor agonist in development for obesity that aims to reduce appetite and boost energy expenditure.

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Medications

Tesofensine

An investigational weight loss tablet that affects three brain chemicals to suppress appetite and support metabolism.

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Foundations

Thermogenesis

Thermogenesis is the body's process of producing heat through metabolic activity, influencing how many calories you burn at rest and during digestion.

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Hormones

Thyroid Function

Thyroid function refers to how well your thyroid gland produces metabolism-regulating hormones — an underactive thyroid can cause weight gain.

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Nutrition

Time-Restricted Eating

An eating pattern where all daily meals are consumed within an 8- to 10-hour window to support metabolic health.

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Medications

Tirzepatide (Mounjaro)

A dual GIP/GLP-1 receptor agonist injection that helps achieve significant weight loss by reducing appetite and improving blood sugar control.

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Medications

Topiramate

Topiramate is a medication originally developed for epilepsy that is used off-label and in combination formulations for weight loss, primarily by reducing appetite.

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Foundations

Total Daily Energy Expenditure (TDEE)

The total calories your body burns each day, used to set a personal calorie target for weight loss.

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Procedures

Transoral Outlet Reduction (TORe)

Transoral outlet reduction is a non-surgical endoscopic procedure that tightens the stomach-intestine connection to restore weight loss after gastric bypass.

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Procedures

Transpyloric Shuttle

The Transpyloric Shuttle is an endoscopic device that delays stomach emptying to promote fullness and support weight loss without surgery.

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Conditions

Type 2 Diabetes

A metabolic disorder where the body cannot effectively use insulin, often linked to weight.

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Nutrition

Ultra-Processed Foods

Industrially manufactured foods linked to overeating and weight gain, and why reducing them is a cornerstone of effective weight management.

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Procedures

Vagal Nerve Blockade (vBloc)

Vagal nerve blockade (vBloc) is an implantable device therapy that intermittently blocks hunger signals between the brain and stomach to promote weight loss.

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Procedures

Vertical Banded Gastroplasty (VBG)

An older restrictive stomach-stapling operation now largely replaced by sleeve gastrectomy and gastric bypass.

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Nutrition

Vinegar and Glycaemic Response

How the acetic acid in vinegar helps lower post-meal blood sugar spikes, supporting glycaemic control and appetite regulation as part of a weight management plan.

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Body Composition

Visceral Fat

Fat stored around internal organs — the most dangerous type of body fat.

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Nutrition

Vitamin D and Weight Management

A nutrient often low in people with obesity, important to check and correct during a weight loss journey.

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Nutrition

Volumetrics Diet

A dietary approach focused on low-calorie-density foods that allow larger, more satisfying portions for fewer calories.

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Screening

Waist-Hip Ratio

A measure of fat distribution — central obesity indicates higher health risk.

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Screening

Water Weight

Temporary fluid retention that can mask true fat loss on the scale.

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Body Composition

Weight Cycling

Weight cycling, or yo-yo dieting, is the repeated pattern of losing and regaining weight, which can slow metabolism and make future weight loss harder.

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Foundations

Weight Loss Plateaus

A normal phase during weight loss where progress stalls due to metabolic adaptation and reduced energy needs.

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Foundations

Weight Maintenance

The long-term phase of weight management focused on sustaining weight loss through continued healthy habits, monitoring, and medical support.

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Foundations

Weight Stigma

Negative attitudes, stereotypes, and discrimination against people based on body weight — a barrier to seeking healthcare that independently worsens health outcomes.

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Medications

Xenical (Orlistat)

A lipase inhibitor that blocks dietary fat absorption for weight management.

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⚕️

This library is for educational purposes only and does not constitute medical advice. Always consult Dr Joseph Wang or a qualified healthcare professional for medical concerns. Accord Medical Clinic Singapore is an MOH-registered medical clinic in Singapore.