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Hormones
Insulin Resistance
A condition where cells do not respond well to insulin, driving weight gain.
PLAIN ENGLISH
Patient-Friendly Explanation
Insulin resistance means your body’s cells do not respond well to insulin, so your pancreas makes more. High insulin promotes fat storage and makes weight loss harder.
MEDICAL
Clinical Definition
Insulin resistance is impaired glucose uptake in response to physiological insulin concentrations. HOMA-IR > 2.5 indicates insulin resistance. It is central to metabolic syndrome pathogenesis.
KEY INSIGHT
Why It Matters
Improving insulin sensitivity through weight loss, exercise, and medications like GLP-1 agonists can break the weight gain cycle and reduce diabetes risk.
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This article is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional for medical concerns. Accord Medical Clinic Singapore is an MOH-registered medical clinic in Singapore. Dr Joseph Wang (Family Physician) provides medical weight management consultations.