Contrave

Contrave is a prescription weight-loss tablet that combines two medications: naltrexone and bupropion. Together, they work on the brain to reduce hunger and control cravings. It is typically prescribed alongside a reduced-calorie diet and increased physical activity.

Contrave is a fixed-dose combination of naltrexone hydrochloride (an opioid antagonist, 8 mg) and bupropion hydrochloride (a norepinephrine-dopamine reuptake inhibitor, 90 mg). Naltrexone blocks beta-endorphin-mediated inhibition of pro-opiomelanocortin (POMC) neurons, while bupropion stimulates POMC neuronal firing, synergistically enhancing anorexigenic signalling in the hypothalamus. Phase III trials (COR) showed 5.4% placebo-subtracted weight loss at 56 weeks.

Contrave targets the neurological pathways involved in food cravings and appetite control, making it particularly useful for patients who struggle with emotional eating. Dr. Joseph Wang can evaluate whether this combination therapy fits your personalised weight loss plan.