Atrial Fibrillation and Obesity
Obesity strongly increases the risk of the irregular heartbeat atrial fibrillation; sustained weight loss can reduce its burden.
Cancer and Obesity
Excess body fat raises the risk of at least 13 cancers through hormonal and inflammatory pathways; weight loss can lower that risk.
Diabesity
The close link between obesity and type 2 diabetes, where losing weight is key to controlling blood sugar.
Obesity-Related Glomerulopathy
Obesity-Related Glomerulopathy is kidney damage caused by excess weight, leading to protein leakage and progressive decline in kidney function.
Hyperuricaemia and Obesity
Hyperuricaemia — elevated blood uric acid — is strongly linked to obesity and can lead to gout; weight loss helps lower uric acid levels naturally.
Bardet-Biedl Syndrome
A rare genetic ciliopathy characterised by severe early-onset obesity caused by impaired hypothalamic appetite regulation, requiring specialised multidisciplinary care.
Infertility and Obesity
Obesity can disrupt hormonal balance and ovulation in both men and women, making it harder to conceive — but weight loss can significantly improve fertility outcomes.
Food Addiction and Obesity
Food addiction is a pattern of compulsive overeating driven by the same brain reward pathways involved in substance addiction, and it is increasingly recognised as a contributor to obesity.
Menopause and Weight Gain
Weight gain driven by declining oestrogen during menopause — shifts fat storage to the abdomen, slows metabolism, and increases cardiometabolic risk.
Lipotoxicity
The damaging effects of excess fat accumulation in organs like the liver, pancreas, and muscles — a key mechanism linking obesity to diabetes and organ dysfunction.