Hyperuricaemia and Obesity

Hyperuricaemia means having too much uric acid in your blood — a condition strongly linked to excess body weight. High uric acid levels can lead to gout (painful joint inflammation) and kidney stones, but the good news is that weight loss can effectively lower uric acid levels.

Hyperuricaemia (serum uric acid above 6.8 mg/dL in men and 6.0 mg/dL in women) is bidirectionally associated with obesity through multiple mechanisms: obesity increases uric acid production via adipokine-mediated xanthine oxidase upregulation while reducing renal urate excretion through insulin resistance-induced sodium retention. Hyperuricaemia is an independent risk factor for hypertension, chronic kidney disease, and metabolic syndrome progression.

Weight loss of as little as 5-10% can significantly lower uric acid levels, often reducing or eliminating the need for urate-lowering medications. At Accord Medical, Dr Joseph Wang can monitor your uric acid levels as part of a holistic weight management programme.