Mazindol

Mazindol is an appetite suppressant that works on the brain hunger control centre. It was historically used for short-term weight management and is being reconsidered in some countries for patients who have not responded to other treatments.

Mazindol is a tetracyclic imidazoisoindole derivative that acts as a norepinephrine and dopamine reuptake inhibitor, suppressing appetite through central anorectic mechanisms distinct from amphetamine-class agents. It also exhibits weak serotonin reuptake inhibition and has been investigated for narcolepsy.

While not a first-line treatment in Singapore, understanding older weight-loss medications helps patients and doctors make informed choices. Dr. Joseph Wang evaluates all available pharmacological options when tailoring a weight management plan for resistant cases.