Hyperinsulinaemia

Hyperinsulinaemia means having too much insulin in your blood. When your body’s cells become resistant to insulin, your pancreas compensates by producing more and more of it. High insulin levels promote fat storage and make it harder to lose weight, creating a challenging cycle that requires targeted dietary and medical strategies to break.

Hyperinsulinaemia is characterised by fasting insulin levels exceeding the normal reference range, typically above 25 μIU/mL, often preceding overt hyperglycaemia by years. It arises from pancreatic β-cell compensation for peripheral insulin resistance and is independently associated with increased cardiovascular risk, enhanced hepatic lipogenesis, and impaired lipolysis. Chronic hyperinsulinaemia drives weight gain by promoting anabolic pathways and suppressing fat oxidation, establishing a feed-forward loop of worsening insulin resistance.

Addressing hyperinsulinaemia is often the key to sustainable weight loss in patients with prediabetes or metabolic syndrome. Dr. Joseph Wang and the Accord Medical team use advanced metabolic testing to identify and treat hyperinsulinaemia as part of a comprehensive weight management programme.