Anorexigenic Signals

Anorexigenic signals are your body’s natural “stop eating” messages. These are chemical messengers that tell your brain you’ve had enough food, helping you feel full and satisfied after a meal.

Anorexigenic signals are neuroendocrine pathways that suppress appetite and promote satiety. Key mediators include leptin (from adipose tissue), peptide YY (PYY) and glucagon-like peptide-1 (GLP-1) from the gut, and alpha-melanocyte-stimulating hormone (α-MSH) in the hypothalamus. Impairment of anorexigenic signalling is a major contributor to obesity.

GLP-1 receptor agonists like semaglutide and tirzepatide work by amplifying anorexigenic signalling — essentially boosting your body’s natural “fullness” messages. Dr Joseph Wang uses these insights to select the most effective treatment for Accord Medical patients.