Adipokines

Adipokines are hormone-like signalling proteins released by your fat cells that communicate with other organs throughout your body. Some adipokines promote healthy metabolism, while others can trigger inflammation. Understanding adipokines helps explain why excess body fat, particularly around the abdomen, can affect whole-body health beyond just weight.

Adipokines are bioactive peptides secreted primarily by white adipose tissue that function as endocrine, paracrine, and autocrine signalling molecules. Key adipokines include leptin (regulates appetite and energy expenditure), adiponectin (enhances insulin sensitivity and has anti-inflammatory properties), resistin (linked to insulin resistance), and pro-inflammatory cytokines such as TNF-α and IL-6. The dysregulation of adipokine secretion in obesity — characterised by leptin resistance and reduced adiponectin — is a central mechanism linking excess adiposity to metabolic disease.

Understanding adipokine biology helps explain why weight loss improves conditions like diabetes and cardiovascular disease beyond just mechanical effects. Dr. Joseph Wang and the team at Accord Medical Clinic use this understanding to provide comprehensive, science-driven weight management care.